July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Retinal capillary blood flow, blood pressure, and ocular perfusion pressure in healthy and glaucomatous females
Author Affiliations & Notes
  • Rana Torabi
    Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    Ophthalmology, University of Pavia, Italy
  • Barbara Wirostko
    Moran Eye Center, Salt Lake City, Utah, United States
  • George Eckert
    Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Jennifer Eikenberry
    Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Chi Wah Rudy Yung
    Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Adrienne Ng
    Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Christian Jonescu-Cuypers
    Ophthalmology, University Hospitals of Geneva, Geneva, Switzerland
  • Brent A Siesky
    Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Rana Torabi, None; Alon Harris, AdOM (C), AdOM (I), CIPLA (C), Oxymap (I), Shire (C); Alice Chandra Verticchio Vercellin, None; Barbara Wirostko, EyeGate (I), EyeGate Pharmaceuticals (E); George Eckert, None; Jennifer Eikenberry, None; Chi Wah Rudy Yung, None; Adrienne Ng, None; Christian Jonescu-Cuypers, None; Brent Siesky, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5618. doi:https://doi.org/
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      Rana Torabi, Alon Harris, Alice Chandra Verticchio Vercellin, Barbara Wirostko, George Eckert, Jennifer Eikenberry, Chi Wah Rudy Yung, Adrienne Ng, Christian Jonescu-Cuypers, Brent A Siesky; Retinal capillary blood flow, blood pressure, and ocular perfusion pressure in healthy and glaucomatous females. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5618. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess the relationship between retinal capillary blood flow, blood pressure (BP) and ocular perfusion pressure (OPP) in females with and without open angle glaucoma (OAG).

Methods : 24 OAG female patients and 16 healthy females participating in the Optic Nerve Formula study at the Glick Eye Institute, Indiana University School of Medicine (Indianapolis, USA), were assessed for baseline retinal capillary blood flow by confocal scanning laser Doppler flowmetry (Heidelberg Retinal Flowmetry), for BP (systolic BP, SBP; diastolic BP, DBP) by an automated ambulatory blood pressure monitor, and for intraocular pressure (IOP) by Goldmann applanation tonometry. OPP was calculated from BP and IOP. Pearson correlations were performed.

Results : In healthy females, systolic OPP was positively correlated with superior retinal capillary blood flow (r=0.41), while this correlation was negative in OAG females (r=-0.37), leading to a statistically significant difference between the two groups (p=0.020). In healthy females, SBP and mean arterial pressure were positively correlated with superior retinal capillary blood flow (r=0.41 and r=0.29); these correlations were negative in OAG females (r=-0.41 and r=-0.44), leading to a statistically significant difference between the two groups (p=0.014 and p=0.031).

Conclusions : The relationship between retinal capillary blood flow, BP and OPP may be influenced by the presence of glaucoma in females.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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