July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Effect of cold provocation on vessel density in eyes with primary open angle glaucoma: an optical coherence tomography angiography study
Author Affiliations & Notes
  • Yu-Chieh Ko
    Taipei Veterans General Hospital, Taipei, Taiwan
  • Wei-Yi Chou
    Taipei Veterans General Hospital, Taipei, Taiwan
  • Mei-Ju Chen
    Taipei Veterans General Hospital, Taipei, Taiwan
  • Catherine Jui-Ling Liu
    Taipei Veterans General Hospital, Taipei, Taiwan
  • Footnotes
    Commercial Relationships   Yu-Chieh Ko, None; Wei-Yi Chou, None; Mei-Ju Chen, None; Catherine Liu, None
  • Footnotes
    Support  This research was supported by the Ministry of Science and Technology of Taiwan (grant numbers: MOST 105-2314-B-075-047, 106-2314-B-075-037) and the Taipei Veterans General Hospital (Taipei, Taiwan; grant number: V107C-114).
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5622. doi:
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    • Get Citation

      Yu-Chieh Ko, Wei-Yi Chou, Mei-Ju Chen, Catherine Jui-Ling Liu; Effect of cold provocation on vessel density in eyes with primary open angle glaucoma: an optical coherence tomography angiography study. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5622.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : The cold pressor test (CPT) induces a cardiovascular response, which may affect ocular blood flow and neuronal function. This study assessed whether optical coherence tomography angiography (OCT-A) can be used to evaluate CPT-induced ocular hemodynamic changes in healthy eyes and in eyes with primary open-angle glaucoma (POAG).

Methods : Twenty-two healthy subjects and 23 subjects with POAG and a retinal fiber layer defect in only one hemifield underwent OCT-A imaging to evaluate CPT-induced vessel density (VD) changes in the peripapillary and macular areas. The CPT was performed by submerging a subject’s right hand in cold water (0–4°C) up to the wrist for 1 minute. Mann-Whitney U tests and Wilcoxon signed-rank tests were used to compare study groups and CPT-induced changes, respectively.

Results : Baseline peripapillary and macular VD measurements were significantly lower in subjects with POAG than in healthy controls (all p < 0.05). Post-CPT VD measurements did not significantly differ from baseline in either healthy or glaucomatous eyes. Additionally , CPT-induced changes in VD did not differ between healthy hemifields in normal eyes and the corresponding undamaged and damaged hemifields in glaucomatous eyes (both p > 0.05). The VD changes also did not differ between damaged and undamaged hemifields in glaucomtous eyes (p > 0.05). Changes in VD were also not significantly influenced by a subject’s self-reported history of cold extremities.

Conclusions : The CPT does not induce significant VD changes, as measured by OCT-A, in the peripapillary or macular areas of either healthy eyes or eyes with POAG. The VD, an all-or-nothing flow measure, may not be sensitive enough for evaluating cold-induced ocular hemodynamic changes.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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