July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Commensals in ocular immunity and autoimmunity
Author Affiliations & Notes
  • Rachel R Caspi
    Laboratory of Immunology, National Eye Inst/NIH, Bethesda, Maryland, United States
  • Footnotes
    Commercial Relationships   Rachel Caspi, None
  • Footnotes
    Support  NIH-NEI intramural funding grant # EY000184 and NIH Bench-to-Bedside award
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5632. doi:https://doi.org/
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      Rachel R Caspi; Commensals in ocular immunity and autoimmunity. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5632. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : Commensal microbiota inhabit all body surfaces, including the gut and the ocular surface. In both cases, they have functional consequences on ocular homeostasis and disease. Using animal models, we demonstrated that the endogenous gut microbiome may promote autoimmune uveitis that damages the neuroretina. In contrast, presence of commensals on the ocular surface is beneficial and protects from pathogenic infections. This presentation will contrast the local and systemic effects of commensal flora on ocular immunity and autoimmunity, and will discuss the mechanisms that may underlie these effects.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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