July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Building and rebuilding the retina one cell at a time
Author Affiliations & Notes
  • Seth Blackshaw
    Neuroscience, Johns Hopkins Univ Sch of Med, Baltimore, Maryland, United States
  • Footnotes
    Commercial Relationships   Seth Blackshaw, None
  • Footnotes
    Support  NIH grants R01EY020560 and U01EY027267
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5637. doi:
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      Seth Blackshaw; Building and rebuilding the retina one cell at a time. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5637.

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      © ARVO (1962-2015); The Authors (2016-present)

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Presentation Description : The retina is an accessible system for identifying the molecular mechanisms that control CNS cell fate specification, and is a prime target for regenerative therapies aimed at restoring photoreceptors lost to blinding diseases. I will discuss our recent large-scale single-cell RNA-Seq analysis of multiple vertebrate species that is aimed at identifying gene regulatory networks that drive the acquisition of neuronal and glial identity in the developing retina. I will discuss our identification of transcription factors that control both temporal identity and proliferative quiescence, new tools we and our collaborators have developed to identify core evolutionarily-conserved gene regulatory networks controlling retinal development, and mechanisms controlling injury-induced neurogenic competence in retinal glia.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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