July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Comparison of the retinal microstructure and visual function after macular hole surgery with and without brilliant Blue G.
Author Affiliations & Notes
  • yuko komiya
    Teikyo University School of Medicine, University Hospital Mizonokuchi, Kanagawa, Kawasaki, Japan
  • Asuka Takeyama
    Teikyo University School of Medicine, University Hospital Mizonokuchi, Kanagawa, Kawasaki, Japan
  • Masaki Shibata
    Teikyo University School of Medicine, University Hospital Mizonokuchi, Kanagawa, Kawasaki, Japan
  • Yutaka Imamura
    Teikyo University School of Medicine, University Hospital Mizonokuchi, Kanagawa, Kawasaki, Japan
  • Masahiro Ishida
    Teikyo University School of Medicine, University Hospital Mizonokuchi, Kanagawa, Kawasaki, Japan
  • Footnotes
    Commercial Relationships   yuko komiya, None; Asuka Takeyama, None; Masaki Shibata, None; Yutaka Imamura, None; Masahiro Ishida, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5761. doi:https://doi.org/
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      yuko komiya, Asuka Takeyama, Masaki Shibata, Yutaka Imamura, Masahiro Ishida; Comparison of the retinal microstructure and visual function after macular hole surgery with and without brilliant Blue G.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5761. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the microstructure of outer retina and the visual function after idiopathic macular hole (MH) surgery with and without brilliant Blue G (BBG) for internal limiting membrane peeling.

Methods : Forty-two eyes of 41 consecutive patients who underwent MH surgery with a 25-gauge system vitrectomy by a single surgeon were included. The eyes were divided into 2 groups: no-dye group and BBG group. The logMAR visual acuities (VA) and optical coherence tomography (OCT) parameters were obtained at baseline and 1, 3, and 6 months after the surgery. Using OCT, MH size were measured, and the length of the defect of the photoreceptor ellipsoid zone (EZ), external limiting membrane (ELM) and interdigitation zone were calculated at each visit.

Results : Twenty three eyes of 23 patients (65.7±6.3 years, 18 females) in no-dye group and 19 eyes of 19 patients (69.4 ± 7.2 years, 7 females) in BBG group were enrolled. There was no difference in age, sex, spherical equivalent, VA and MH size between the two groups. The operation time did not show difference between two groups. The rate of closure after one surgery was 96% (22/23 eyes) for the no-dye group, versus 100% (19/19 eyes) for the BBG group. In the 41 eyes whose MH was closed, the lengths of the defect of EZ and interdigitation zone were significantly shorter postoperatively in both groups.
Deficiency of ELM completely recovered in 81.8% at 3 months in no-dye group and 89.4% in BBG group at 1 month. The improvement of logMAR VA was significantly greater in BBG group than in no-dye group at 1, 3, 6 months (Mann-Whitney test, P = 0.002, 0.008, 0.004, respectively). The rates of changes in deficiency of EZ at 1 and 6 months compared with baseline in BBG group were significantly greater than those in no dye group. (Mann-Whitney test, p=0.047 and 0.010, respectively).

Conclusions : The eyes undergoing BBG-assisted MH surgery appear to gain greater visual improvement than those without staining. Possible neuroprotective effect of BBG may contribute to early functional and anatomical outcomes.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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