July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Choroidal vascular remodeling in experimental mouse models: Ultra-widefield angiographic analysis
Author Affiliations & Notes
  • Junyeop Lee
    Department of Ophthalmology, Yeungnam University, Daegu, Korea (the Republic of)
  • Yeong A Choi
    Department of Ophthalmology, Yeungnam University, Daegu, Korea (the Republic of)
  • Sang A Kim
    Department of Ophthalmology, Yeungnam University, Daegu, Korea (the Republic of)
  • Jehwi Jeon
    Department of Ophthalmology, Yeungnam University, Daegu, Korea (the Republic of)
  • Doyeon Kim
    Department of Ophthalmology, Yeungnam University, Daegu, Korea (the Republic of)
  • Anna Kim
    Department of Ophthalmology, Yeungnam University, Daegu, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Junyeop Lee, None; Yeong A Choi, None; Sang A Kim, None; Jehwi Jeon, None; Doyeon Kim, None; Anna Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5874. doi:
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    • Get Citation

      Junyeop Lee, Yeong A Choi, Sang A Kim, Jehwi Jeon, Doyeon Kim, Anna Kim; Choroidal vascular remodeling in experimental mouse models: Ultra-widefield angiographic analysis. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5874.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the structural and functional characteristics of choroidal blood vessels in normal mice and disease models using an ultra-widefield indocyanine green angiography (UWF ICGA)

Methods : We evaluated age-related changes of choroidal vascular system in C57BL/6 wild-type mice using UWF ICGA (Optos® California) and compared with Heidelberg Retina Angiograph (HRA). Choroidal vascular changes in Laser-induced choroidal neovascularization (LICNV) and oxygen-induced retinopathy (OIR) models were analyzed with UWF ICGA.

Results : Serial UWF ICGA demonstrated that medium- and large-sized choroidal blood vessels are remodeled with aging. Compared to the HRA system, UWF ICGA enabled the better and wider visualization of the entire choroidal vascular structure. Choroidal hyperpermeability and vascular staining were observed in OIR models. UWF ICGA provided high enough resolution to visualize the serial quantifications of CNV accompanied by feeder vessel in LICNV.

Conclusions : UWF ICGA provides excellent in vivo imaging of choroidal vascular networks in normal mice and disease models. Choroidal blood vessels continuously remodel during development, aging and disease progression. UWF ICGA will be a crucial imaging modality for studying the structure and function of choroidal blood vessels in experimental animals.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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