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Shin-ichi Ikeda, Toshihide Kurihara, Xiaoyan Jiang, Masataro Toda, Kazuo Tsubota; Oral lactoferrin administration suppresses lens-induced myopia in mice. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5890. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Recent studies showed an association between myopia development and local ocular inflammation. Lactoferrin (LF) is hemeprotein being contained in saliva, tear and mother’s milk, which has antibacterial activity through chelating iron ion. It is also known that LF also has an anti-inflammatory effect. In this study, we sought to determine whether LF has a suppressive effect against myopia progression using murine lens-induced myopia (LIM) model.
Male C57BL/6J mice (3 weeks old, n=8) were divided into two groups, one group orally administrated LF (1600mg/kg/day, from 3-week-old to 7-week-old) and the other group administrated same volume of ringer solution as a control. At 4-week-old, mice were subjected to wear -30 diopter (D) lens on right eye and flame without lens on left eye, respectively. Before and 3 weeks after wearing (at 4-week-old and 7-week-old), the refraction and the axial length were measured using a refractometer and a SD-OCT system in both eyes.
In ringer-administrated group, minus lens-worn eyes showed a refractive error shift (means ± standard deviation, flame eyes: +1.01±2.79 D, -30D eyes: -10.12±3.98 D, p=0.001) and an axial length elongation (difference of axial length, frame eyes: 0.162±0.019 mm, -30 D eyes: 0.204±0.017 mm, p=0.012) indicating a successful induction of myopia in C57BL6/J mice. On the other hands, in LF group, there are no significant differences in refractive error (means ± standard deviation, flame eyes: -1.45±2.10 D, -30D eyes: -5.82±2.30 D, p=0.195) and axial length elongation (difference of axial length, frame eyes: 0.166±0.011 mm, -30 D eyes: 0.175±0.014 mm, p=0.849) .
Present study demonstrated that oral administration of LF suppressed lens-induced myopia development in mice.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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