July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Electrophysiological and pupillometric measures of inner-retina function in non-proliferative diabetic retinopathy
Author Affiliations & Notes
  • Jason C Park
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
  • J Jason McAnany
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
    Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, United States
  • Footnotes
    Commercial Relationships   Jason Park, None; J Jason McAnany, None
  • Footnotes
    Support  R01EY026004 (JJM), The Illinois Society for the Prevention of Blindnes Research Grant (JJP)
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5958. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Jason C Park, J Jason McAnany; Electrophysiological and pupillometric measures of inner-retina function in non-proliferative diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5958.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To evaluate three measures of inner-retina function, the pattern electroretinogram (pERG), the photopic negative response (PhNR), and the post-illumination pupil response (PIPR), in diabetics who have different stages of non-proliferative diabetic retinopathy (NPDR).

Methods : Fifteen non-diabetic control subjects and 45 type 2 diabetic subjects (15 have no clinically-apparent retinopathy [NDR], 15 have mild NPDR, and 15 have moderate/severe NPDR) participated. The pERG was elicited by a contrast reversing checkerboard pattern and the PhNR was elicited by a full-field, long-wavelength (642 nm), flash presented against a short-wavelength adapting field (465 nm). The PIPR was elicited by a 1-sec, full-field, 450 cd/m2, short-wavelength flash (465 nm) after dark adaptation. All responses were recorded and analyzed using conventional techniques. One-way analysis of variance (ANOVA) with Holm-Sidak multiple comparisons were performed to compare the pERG, PhNR, and PIPR among the control and patient groups.

Results : ANOVA indicated statistically significant differences among the subject groups for all three measures (all F > 4.73, p < 0.01). Follow-up comparisons indicated small, non-significant reductions in the pERG (8%), PhNR (8%), and PIPR (10%) for the NDR group compared to the controls. In contrast, there were significant reductions in the pERG (31%), PhNR (30%), and PIPR (28%) for the mild NPDR group compared to the controls. Likewise, there were significant reductions in the pERG (40%), PhNR (32%), and PIPR (32%) for the moderate/severe NPDR group compared to the controls.

Conclusions : Abnormalities of the pERG, PhNR, and PIPR provide evidence for inner-retina neural dysfunction in diabetics who have clinically-apparent vascular abnormalities. Taken together, these measures provide a non-invasive, objective approach to study neural dysfunction of the inner-retina in these individuals.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×