July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Visualization of cone cells without adaptive optics
Author Affiliations & Notes
  • Yasuki Ito
    Ophthalmology, Nagoya Univ Graduate School of Medicine, Nagoya, AICHI, Japan
  • Jun Takeuchi
    Ophthalmology, Nagoya Univ Graduate School of Medicine, Nagoya, AICHI, Japan
  • Keiko Kataoka
    Ophthalmology, Nagoya Univ Graduate School of Medicine, Nagoya, AICHI, Japan
  • Hiroko Terasaki
    Ophthalmology, Nagoya Univ Graduate School of Medicine, Nagoya, AICHI, Japan
  • Footnotes
    Commercial Relationships   Yasuki Ito, Heidelberg Engineering (F); Jun Takeuchi, None; Keiko Kataoka, None; Hiroko Terasaki, Heidelberg Engineering (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6092. doi:
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    • Get Citation

      Yasuki Ito, Jun Takeuchi, Keiko Kataoka, Hiroko Terasaki; Visualization of cone cells without adaptive optics. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6092.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Adaptive optics (AO) fundus camera or scanning laser ophthalmoscope (SLO) has been used to visualize the cone cells in the fundus. This study was performed to test the hypothesis that cone cells can be visualized without using AO.

Methods : Fundus images were taken in 15 eyes of 10 subjects (3 men and 7 women) using Spectralis® SLO with high magnification module. The light source of Spectralis SLO was 820 nm. Scan angle was 8 x8 degrees (1536 x1536 or 768 x 768 pixels) with the high magnification module. The pupils were dilated in 5 eyes and were not dilated in 10 eyes. In 7 eyes, cone density was measured at the normal location around 6 degrees temporal from the foveal center.

Results : Cone cell mosaic could be visualized in 10 eyes of 15 eyes (67%). Image quality varied depending on the age, suggesting the importance of the lens opacity to visualize cone cell mosaic. Dryness of cornea, astigmatism also degraded image quality. Cone density at 6 degrees was 12106 ± 1230 cells/mm2.

Conclusions : Cone cells could be visualized without using AO system in eyes with good optics. Because the SLO system has been used worldwide, high magnification module may be an easy and useful option to evaluate cone cells in eyes with good optics, although the resolution is better in the AO system.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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