Abstract
Purpose :
The aim of this study was to evaluate the correlation between digital photography derived optic nerve cup-to-disc ratios (CDR) and those obtained using spectral-domain optical coherence tomography (OCT) in pediatric glaucoma suspects.
Methods :
This was a retrospective, observational study undertaken at a university setting. Clinical records of pediatric subjects, aged 5-15 years, who presented with large optic nerve CDRs (CDR≥0.5) as determined by indirect ophthalmoscopy were included in the study. The CDRs were quantitatively assessed using a 30° digital fundus photography and the mean CDR was calculated by averaging the horizontal and vertical CDRs from digital images. The OCT derived CDRs were calculated through measurement of Bruch’s membrane opening and the central retinal nerve fiber layer free zone in both horizontal and vertical sections of the OCT images. All OCT images were acquired using a spectral-domain optical coherence tomography (OCT) (Spectralis® OCT, Heidelberg Engineering). Only one eye (right) of study subjects were included for analysis. Pearson correlation analysis was used to evaluate the association between CDRs determined by fundus photography (D30-CDR) with OCT derived CDRs (OCT-CDR) and with clinically determined CDRs (Oph-CDR).
Results :
Twenty-two subjects (11M/11F) with a mean age of 10.3±2.9 years were included in the study. The mean D30-CDR (0.665±0.048) was strongly correlated with both the mean OCT-CDR (0.650±0.051) (r=0.524; p=0.012) and the mean Oph-CDR (0.689±0.067) (r=0.558; p=0.007). There was a stronger correlation between the vertical D-30 CDR and vertical OCT-CDR (r=0.602; p=0.003) compared to that of horizontal D-30 CDR and horizontal OCT-CDR (r=0.442; p=0.039). Furthermore, only the vertical but not the horizontal D30-CDR parameter was correlated to a significant extent with the mean OCT-CDR (r=0.562; p=0.006 vs. r=0.407; p=0.060) and the Oph-CDR (r=0.628; p=0.002 vs. r=0.408; p=0.060).
Conclusions :
Fundus image derived CDR measurements reveal a moderate-strong correlation with both OCT derived CDRs and clinically measured CDRs in pediatric glaucoma suspects. There appears to be a more robust relationship between vertical D-30 CDR parameter and OCT derived CDR compared to its horizontal counterpart.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.