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Brandon Wong, Sasan Moghimi, Linda M Zangwill, Huiyuan Hou, Rafaella Penteado, Patricia Manalastas, Elham Ghahari, Christopher Bowd, Robert N Weinreb; Optic Nerve Vessel Density in Glaucoma Patients of African and European descent. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6180.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate racial differences in optic nerve head (ONH) vessel density parameters measured by optical coherence tomography angiography (OCTA) in patients with open-angle glaucoma
326 eyes of 199 glaucoma patients, and 100 eyes of 58 healthy subjects from the Diagnostic Innovations in Glaucoma Study with OCTA images were included. Circumpapillary capillary density (cpCD), and 6 Garway-Heath sectors were measured after removing the large vessels from OCTA images. Pattern of vessel density loss in European-descent (ED) and African-descent (AD) participants were explored and areas under the receiver operating characteristic curves (AUROC) were used to evaluate diagnostic accuracy in each ethnic group after adjusting for confounders.
AD and ED subjects with glaucoma had comparable age and visual field MD (mean deviation). After adjusting for age, disc area and other confounders, significant lower cpCD was found in ED eyes compared to AD in early glaucoma (44.97±5.04 and 48.59±4.32 %, respectively; P <0.001) and moderate to advanced glaucoma (33.93±6.61 and 39.08±6.61 %, respectively; P=0.001). Although estimated vessel density loss was greater in all sectors in ED subjects, similar pattern of density loss was observed in both racial group with temporal sector being the least affected region. Lower MD and older age were associated with lower cpCD in both ethnicities in multivariable model. The AUROC of cpCD for discriminating between healthy and glaucomatous eyes was higher for ED (0.88) compared to AD (0.69) (p=0.003).
A significantly lower cpCD in ED subjects was found compared to AD subjects in eyes with similar severity of glaucoma. Although ONH vessel density parameters had a good diagnostic ability in detecting glaucoma in ED, their ability was modest in AD patients.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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