July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Determinants of Lamina Cribrosa Depth in Asian Eyes
Author Affiliations & Notes
  • Tin A Tun
    Clinic, Singapore Eye Research Institute, Singapore, Singapore
  • Xiaofei Wang
    Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China, China
  • Tin Aung
    Glaucoma, Singapore National Eye Centre, Singapore, Singapore
  • Ching-Yu Cheng
    Clinic, Singapore Eye Research Institute, Singapore, Singapore
  • Michael J A Girard
    Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Tin Tun, None; Xiaofei Wang, None; Tin Aung, None; Ching-Yu Cheng, None; Michael Girard, None
  • Footnotes
    Support  National Medical Research Council, Singapore
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6194. doi:https://doi.org/
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      Tin A Tun, Xiaofei Wang, Tin Aung, Ching-Yu Cheng, Michael J A Girard; Determinants of Lamina Cribrosa Depth in Asian Eyes. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6194. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the factors influencing anterior lamina cribrosa depth (LCD) in Asian eyes and compare LCD between healthy and glaucoma eyes.

Methods : The optic nerve heads of 1,396 healthy [628 Chinese descent (CD) and 768 Indian descent (ID) subjects] and 331 glaucoma subjects [201 primary open angle glaucoma (POAG) and 130 primary angle closure glaucoma (PACG) cases] were imaged with optical coherence tomography (OCT, Spectralis, Heidelberg, Germany). The B scans were aligned to the foveal-Bruch’s membrane opening (BMO) axis. LCD was defined as the distance from the BMO (LCD-BMO) or the peripapillary sclera (LCD-PPS) reference plane to the laminar surface.

Results : On average, LCD-BMO was 436.40±99.41 µm (95% CI, 431.18, 441.62) in healthy eyes, 477.1±120.2 µm (95% CI, 460.38, 493.82) in POAG and 484.6±129.21 µm (95% CI, 462.18, 507.03) in PACG eyes. The LCD-PPS was 378.72±105.50 µm (95%CI, 373.18, 384.26) in healthy eyes, 452.61±123.08 µm (95% CI, 435.49, 469.73) in POAG and 469.76±131.93 µm (95% CI, 446.87, 492.65) in PACG eyes. Both LCDs in healthy eyes were significantly different between two races (LCD-BMO: 429.63±95.31 µm in CD vs 441.93±102.38 µm in ID, P=0.021; and LCD-PPS: 363.73±94.78 µm in CD vs 390.98±112.10 µm in ID, P<0.001). There was significant difference of LCDs between normal and POAG or PACG (all P <0.001) but no difference of LCDs was found between POAG and PACG (all P>0.05). In the multivariable regression analysis, the LCD-PPS of the healthy eyes was 31.81 µm shallower in females, 28.11 µm deeper in ID subjects, 7.95 µm shallower for 1 mm increase in axial length (Axl), and 0.48 µm deeper for 1 µm increase in ChT.

Conclusions : The LCD was influenced by age, gender, race, axial length, choroidal thickness, and glaucoma. This LCD database may facilitate a more accurate assessment of ONH’s cupping using OCT in Asian populations.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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