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yuichi yasukura, Atsuya Miki, Shizuka Koh, Naoyuki Maeda, Kohji Nishida; Influence of prostaglandin analogues on corneal biomechanical parameters measured with a dynamic Scheimpflug analyzer. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6197.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the influence of topical prostaglandin analogues on corneal biomechanical properties measured with a dynamic Scheimpflug analyzer with multivariable correlation analyses controlling for other baseline factors such as axial length, intraocular pressure (IOP) and central corneal thickness (CCT).
Twenty-four eyes of 24 consecutive subjects with glaucoma who underwent measurement of biomechanical parameters with a dynamic Scheimpflug analyzer (Corvis ST) before and after initiation of treatment with topical prostaglandin analogue were retrospectively investigated. All patients had no history of any glaucoma treatment prior to study initiation and no other glaucoma treatment during the study period. Twenty-two of 36 biomechanical parameters were selected for analyses based on measurement reliability and clinical relevance. The biomechanical parameters before and after prostaglandin analogue treatment were compared using paired t-test. The parameters that showed nearly significant difference (P<0.1) were further evaluated with multivariable models adjusting for axial length, IOP and CCT.
Seven out of 22 biomechanical parameters showed statistically significant (P<0.05) difference in multivariable models. Prostaglandin analogue therapy caused significant increase in highest concavity (HC) deflection amplitude, peak distance, and HC deflection ratio max (1mm and 2mm), whereas prostaglandin analogue therapy caused decrease in time at applanation 2. These results consistently indicate increase in deformability of the cornea in eyes with prostaglandin analogue therapy. Many biomechanical parameters showed significant correlation with other baseline factors (9 parameters with IOP, 6 parameters with CCT, and 3 parameters with axial length).
Topical prostaglandin analogue therapy showed significant influence on many of the corneal biomechanical parameters measured with a dynamic Scheimpflug analyzer. Results of the correlation analyses consistently showed increase of corneal deformability after initiation of prostaglandin analogue treatment. These results suggest the possibility that the changes in corneal biomechanical properties caused by prostaglandin analogue therapy may lead to overestimation of IOP lowering effects.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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