Abstract
Purpose :
Corvis ST measures non-invasively the displacement of the orbital bulb in response to an air pulse, thus describing the biomechanical properties of the orbital tissue. A previous pilot study has shown that the derived parameters Whole Eye Movement (WEM-length and time) are well suited for the diagnosis of endocrine orbitopathy (EO).
The aim of this study was to examine whether the WEM parameters are able to differentiate between active and inactive EO and can be used as parameters for a course assessment of the disease.
Methods :
WEM parameters from 43 patients with inactive EO were compared with results from 12 patients with active EO and 43 healthy volunteers. 1 eye per patient was selected for evaluation. The groups were correlated according to age and intraocular pressure. The statistical analysis was performed using SPSS 25.
Results :
The descriptive statistics showed no significant differences between the 3 groups. For the parameter WEM length a statistically significant difference was found between healthy subjects and EO- patients (mean difference inactive - healthy: -0.10, active - healthy: -0.12, p <0.001). There was no significant difference between active and inactive EO (+0.02, p = 0.736). The parameter WEM time showed similar results. The comparison between healthy and disease showed highly significant differences (inactive / healthy: -1.24, p <0.001, for active / healthy: -0.99, p = 0.007). There was no difference between active and inactive EO (-0.25, p = 1.0). In the comparison healthy versus disease, the ROC curve showed high specificity and sensitivity values for both WEM parameters (WEM length: 79% / 80%, WEM time: 80% / 79%).
Conclusions :
The WEM parameters are not suitable for distinguishing between inactive and active EO, but can be used as a test between disease and healthy eyes.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.