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Chiara Del Noce, Aldo Vagge, Carlo Enrico Traverso; Evaluation of choroidal thickness and choroidal vascular blood flow in patients with Thyroid Associated Orbitopathy (TAO) using SD-OCT and Angio-OCT. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6209.
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The aim of this study was to evaluate changes in choroidal thickness and in choroidal vascular blood flow in patients with TAO and their relationship with clinical features and disease activity using SD-OCT and Angio-OCT technology.
Eighteen patients and control subjects underwent a complete eye examination, OCT and angio - OCT. We also manually obtained other angiographic scans at 3 different consecutive levels (L1, L2 and L3) below the choriocapillary. According to EUGOGO (European Guidelines for Europeans Basedow ophthalmopathy), patients were divided into mild, moderate or severe TAO.
The subfoveal choroid was significantly thicker in TAO patients than the control eyes (285.6275 ± 32.5 μm compared to 135.89 ± 19.8 μm, respectively, p = 0.0089). The correlation analysis in the TAO group showed a significant correlation between the choroidal thickness and EUGOGO clinical score (r = 0.84, p = 8.44032E - 07). Regarding the vascular flow data, statistically significant differences were found in the levels of choriocapillary and L3: vascular flow of choriocapillary was markedly reduced in subjects with TAO compared to healthy subjects (49.78 ± 4.5 vs. 53.36 ± 1.07; p = 2.5105E - 07); vascular flow of the deeper layer L3 resulted higher in subjects with TAO than in healthy subjects (46.9 ± 20.23 and 41.475 ± 3.06; p = 0.01168).
We observed that subfoveal choroidal thickness and choroidal blood flow were significantly different in patients with TAO compared to healthy subjects. According to our results we can state that it is reasonable to use those values as a new parameter in the evaluation of patients with TAO to estimate the degree of orbital congestion.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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