Abstract
Purpose :
The potentiation of ocular surface disease in patients undergoing ptosis repair has long been expressed throughout ophthalmic literature. This study aims to evaluate the effect of ptosis repair on tear film lipid layer thickness (LLT) and subjective dry eye symptoms.
Methods :
This is a prospective, non-randomized, controlled study. Patients who were evaluated and scheduled to undergo ptosis repair as part of their routine care were included in the study. Patients undergoing these procedures for any indication were included. The eye undergoing the surgical procedure was enrolled in the treatment arm. Patients undergoing unilateral procedures had the fellow enrolled in the control arm. Tear film lipid layer thickness measurements were obtained for each eye both pre-operatively and at the 1-month post-operative visit. Similarly, an OSDI was obtained for each eye both pre-operatively and at the 1-month post-operative visit.
Results :
A total of 5 eyes from 4 patients have been enrolled in the treatment arm. A total of 2 eyes from 2 patients were enrolled in the control arm. The mean time to follow-up in both arms was 5.25 weeks.Mean pre-operative lipid layer thickness (LLT) was 91.2 nm (standard deviation 11.2 nm) in the treatment arm and 84.5 nm (standard deviation 1.5 nm) in the control arm. Mean pre-operative OSDI score was 11.2 (standard deviation 6.3) in the treatment arm, and 11.0 (standard deviation 2.0) in the control arm. The mean post-operative lipid layer thickness was 93.0 nm (standard deviation 10.1 nm) in the treatment arm and 66.0 nm (standard deviation 4.0 nm) in the control arm. The mean post-operative OSDI score was 11.0 (standard deviation 2.0) in the treatment arm and 11.5 (standard deviation 7.8) in the control arm.
Conclusions :
The results of this study indicate that ptosis repair surgery does not appear to negatively impact Tear Film Lipid Layer Thickness (LLT) as measured by the Lipiview 2 interferometer (TearScience), nor cause significant change in subjective dry eye symptoms as evaluated by the Ocular Surface Disease Index (OSDI). Recruitment is ongoing to increase enrollment and allow for further stastical analysis. The initial findings of this study show promise in illustrating that, in the appropriately selected patient, ptosis repair can be performed without negatively impacting the tear film Lipid Layer Thickness (LLT) or subjective dry eye symptoms.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.