July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Long-term outcomes on lens clarity after lens-sparing vitrectomy for persistent fetal vasculature syndrome
Author Affiliations & Notes
  • Irina De la Huerta
    Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, United States
  • Mavis Gappy
    Oakland University William Beaumont School of Medicine, Auburn Hills, Michigan, United States
  • Kimberly A Drenser
    Associated Retinal Consultants, P.C., Novi, Michigan, United States
  • Antonio Capone
    Associated Retinal Consultants, P.C., Novi, Michigan, United States
  • Michael Thomas Trese
    Associated Retinal Consultants, P.C., Novi, Michigan, United States
  • Footnotes
    Commercial Relationships   Irina De la Huerta, None; Mavis Gappy, None; Kimberly Drenser, None; Antonio Capone, None; Michael Trese, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6422. doi:https://doi.org/
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      Irina De la Huerta, Mavis Gappy, Kimberly A Drenser, Antonio Capone, Michael Thomas Trese; Long-term outcomes on lens clarity after lens-sparing vitrectomy for persistent fetal vasculature syndrome. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6422. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The long-term outcomes of lens-sparing vitreous surgery for combined anterior and posterior persistent fetal vasculature syndrome (PFVS) with nonaxial lens opacification have not been well characterized. We performed a retrospective case series study to describe the long-term effect on lens clarity of lens-sparing vitrectomy for PFVS.

Methods : A retrospective chart review was conducted of patients who underwent lens-sparing vitrectomy for tractional retinal detachments associated with combined anterior and posterior PFVS with nonaxial lens opacification between 2006 and 2015 at a single tertiary referral pediatric vitreoretinal practice. Patients with at least 3 years of postoperative follow-up were included. Patients were excluded if any surgery had been performed at an outside institution before referral, or if they had genetic testing results or a known family history consistent with familial exudative vitreoretinopathy or Norrie disease. The main outcome measures were retinal reattachment after lens-sparing vitrectomy, cataract extraction after lens-sparing vitrectomy, lens status at the last follow-up and best corrected visual acuity at the last follow-up.

Results : Eleven eyes of 10 patients (6 male and 4 female) met the inclusion criteria for the study. The mean age at the time of lens sparing vitrectomy was 6.25 months (range: 0.5 months – 5 years). The average postoperative follow-up time was 7.6 years (range: 3 – 11 years). The reattachment rate after a single lens-sparing vitrectomy surgery was 81.8% (9 of 11 eyes). Reattachment was achieved after a second lens-sparing vitrectomy in one eye, and one eye was found to have an inoperable redetachment. Cataract extraction was performed in 3 eyes (27.3%) due to progressive lens opacity at an average of 1.4 years (range: 1 -2 years) after the lens sparing vitrectomy. At the last follow-up 90.9% (10 of 11 eyes) were attached. 72.7% (8 of 11) were phakic, 18.2% (2 of 11) were pseudophakic, and one eye was aphakic. Best corrected visual acuity was 20/158 (range: 20/30 – NLP).

Conclusions : Lens clarity is observed in most eyes after lens-sparing vitrectomy for combined anterior and posterior PFVS with nonaxial lens opacification. Cataract extraction, when necessary, is most often performed 1-2 years following lens-sparing vitrectomy.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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