July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study
Author Affiliations & Notes
  • Yee Ling Wong
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    R&D Vision Sciences AMERA, Essilor International, Singapore, Singapore
  • Charumathi Sabanayagam
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
  • Chee Wai Wong
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
  • Anna Chwee-Hong Yeo
    R&D Vision Sciences AMERA, Essilor International, Singapore, Singapore
  • Yin-Bun Cheung
    Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
  • Gemmy Chui Ming Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
  • Audrey Chia
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
  • Anthony N Kuo
    Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States of America, North Carolina, United States
  • Kyoko Ohno-Matsui
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan, Japan
  • Tien Y Wong
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
  • Jie-Jin Wang
    Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
  • Ching-Yu Cheng
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
  • Quan V Hoang
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
  • Ecosse Luc Lamoureux
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
  • Seang-Mei Saw
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Yee Ling Wong, Essilor International, Singapore (E); Charumathi Sabanayagam, None; Chee Wai Wong, None; Anna Chwee-Hong Yeo, Essilor International, Singapore (E); Yin-Bun Cheung, None; Gemmy Cheung, None; Audrey Chia, None; Anthony Kuo, None; Kyoko Ohno-Matsui, None; Tien Wong, None; Jie-Jin Wang, None; Ching-Yu Cheng, None; Quan Hoang, None; Ecosse Lamoureux, None; Seang-Mei Saw, None
  • Footnotes
    Support  This study is supported by the National Medical Research Council (grants: 0796/2003, IRG07nov013, IRG09nov014, STaR/0003/2008, CG/SERI/2010, CIRG/1417/2015, CIRG/1488/2018, OFLCG/004a/2018), Biomedical Research Council (grants: 08/1/35/19/550, 09/1/35/19/616, 501/25-5), Economic Development Board-Essilor Post-graduate Programme (S14-1103-IPP), Singapore.
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6453. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Yee Ling Wong, Charumathi Sabanayagam, Chee Wai Wong, Anna Chwee-Hong Yeo, Yin-Bun Cheung, Gemmy Chui Ming Cheung, Audrey Chia, Anthony N Kuo, Kyoko Ohno-Matsui, Tien Y Wong, Jie-Jin Wang, Ching-Yu Cheng, Quan V Hoang, Ecosse Luc Lamoureux, Seang-Mei Saw; Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6453.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To examine the person-specific cumulative 6-year incidence and progression of myopic macular degeneration (MMD) and associated risk factors in Singapore.

Methods : We analysed data from phakic adults who attended the baseline (aged ≥40 years, 2004-2011) and 6-year follow-up (2011-2017) visits of a population-based longitudinal study (Singapore Epidemiology of Eye Diseases study). Eye examinations, including subjective refraction and axial length (AL) were done. MMD was graded using the META-PM classification from fundus photographs. Incidence of MMD was defined as development of MMD (Meta-PM category 2, 3 or 4) during follow up in those without MMD at baseline and progression of MMD as worsening of MMD in those with pre-existing MMD.

Results : In 8,716 phakic persons at baseline, 6,080 (69.8%) were re-examined. Of these, 6,030 (99.2%) had gradable fundus photographs and were analysed. Of 6030, 35.8% had myopia (spherical equivalent [SE] ≤-0.5 diopters [D]) and 6.4% had high myopia (SE ≤-5.0 D), respectively, with 2,009 at risk of MMD development. Mean baseline age (±SD) was 56.1±8.7 years (28.9% Malays, 32.1% Indians and 39.0% Chinese).

The 6-year incidence of MMD was 1.7% (95% confidence interval [CI], 1.2-2.3%). Of the 35 new MMD cases (42 eyes), 33 (40 eyes), 2 (2 eyes) and 1 (1 eye) had incident diffuse chorioretinal atrophy, patchy chorioretinal atrophy and lacquer cracks, respectively.

Among 202 persons with MMD at baseline, the 6-year progression of MMD was 17.3% (95% CI, 12.1-22.6%) and stable MMD was seen in 167 (82.7%). Of 35 persons (49 eyes) with MMD progression, 4 (6 eyes) progressed from Meta-PM category 2 to 3 with new patchy chorioretinal atrophy; 24 (35 eyes) had enlargement of existing diffuse chorioretinal atrophy; 7 (7 eyes) had enlargement of existing patchy chorioretinal atrophy; 4 (4 eyes) had widening lacquer cracks; and 3 (5 eyes) had new lacquer cracks.

Having tessellated fundus at baseline predicted MMD development at 6 years (P<0.001). Older age (P<0.001), worse SE (P=0.005) and longer AL (P=0.002) was associated with MMD incidence. Having peripapillary intrachoroidal cavitation (P=0.004), worse SE (P=0.03) and longer AL (P=0.009) was associated with MMD progression.

Conclusions : In the 6-year period, MMD was stable in majority of older adults in Singapore, with a low incidence of MMD (1.7%) and relatively low progression (17.3%) in those with existing MMD.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×