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Jack TIAN, Martin Garcia, Alfredo A Sadun, Stuart G Coupland, Rustum Karanjia, Kenneth Lu; Pattern ERG as an Objective Outcome Measure of Contrast Sensitivity in Patients with Multifocal Intraocular Lenses. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6466.
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© ARVO (1962-2015); The Authors (2016-present)
The purpose of this study was to use pattern electroretinograms (pERG) as an objective way to quantify contrast sensitivity function in pseudophakic patients.
An ISCEV compliant 0.75 cycles per degree pERG protocol at six different contrast intensities (100% to 75%) was tested on pseudophakic patients with 4 different intraocular lens (IOL) types (monofocal (n=7), diffractive multifocal (n=7), accommodating (n=5), and extended focus lenses (n=10)) The N95 amplitude was compared between groups with an unpaired students t-test.
There was a linear decrease in N95 amplitude as the contrast intensities decreased across all subject groups. The N95 amplitude was significantly decreased in subjects with diffractive multifocal IOLs when compared to the other groups (p<0.001). There was no statistical difference between the other three groups of IOLs.
Pattern ERG N95 values can be used to objectively quantify contrast sensitivity in pseudophakic patients. Diffractive multifocal IOLs significantly decreased N95 values across all contrast sensitivities when compared to other types of IOLs. This measured loss of contrast sensitivity may account for why some patients who, despite normal visual acuity, encounter difficulty with diffractive IOLs.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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