July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Pattern ERG as an Objective Outcome Measure of Contrast Sensitivity in Patients with Multifocal Intraocular Lenses
Author Affiliations & Notes
  • Jack TIAN
    Flaum Eye Institute, California, United States
  • Martin Garcia
    Ophthalmology, David Geffen School of Medicine, Los Angeles, California, United States
  • Alfredo A Sadun
    Doheny Eye Center, California, United States
    Doheny Eye Institute, California, United States
  • Stuart G Coupland
    University of Ottawa Eye Institute, Ontario, Canada
    Ottawa Hospital Research Institute, Ontario, Canada
  • Rustum Karanjia
    University of Ottawa Eye Institute, Ontario, Canada
    Ottawa Hospital Research Institute, Ontario, Canada
  • Kenneth Lu
    Doheny Eye Center, California, United States
    Doheny Eye Institute, California, United States
  • Footnotes
    Commercial Relationships   Jack TIAN, None; Martin Garcia, None; Alfredo Sadun, None; Stuart Coupland, None; Rustum Karanjia, None; Kenneth Lu, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6466. doi:
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      Jack TIAN, Martin Garcia, Alfredo A Sadun, Stuart G Coupland, Rustum Karanjia, Kenneth Lu; Pattern ERG as an Objective Outcome Measure of Contrast Sensitivity in Patients with Multifocal Intraocular Lenses. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6466.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The purpose of this study was to use pattern electroretinograms (pERG) as an objective way to quantify contrast sensitivity function in pseudophakic patients.

Methods : An ISCEV compliant 0.75 cycles per degree pERG protocol at six different contrast intensities (100% to 75%) was tested on pseudophakic patients with 4 different intraocular lens (IOL) types (monofocal (n=7), diffractive multifocal (n=7), accommodating (n=5), and extended focus lenses (n=10)) The N95 amplitude was compared between groups with an unpaired students t-test.

Results : There was a linear decrease in N95 amplitude as the contrast intensities decreased across all subject groups. The N95 amplitude was significantly decreased in subjects with diffractive multifocal IOLs when compared to the other groups (p<0.001). There was no statistical difference between the other three groups of IOLs.

Conclusions : Pattern ERG N95 values can be used to objectively quantify contrast sensitivity in pseudophakic patients. Diffractive multifocal IOLs significantly decreased N95 values across all contrast sensitivities when compared to other types of IOLs. This measured loss of contrast sensitivity may account for why some patients who, despite normal visual acuity, encounter difficulty with diffractive IOLs.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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