July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Optical and visual quality with physical and visually simulated presbyopic multifocal contact lenses
Author Affiliations & Notes
  • Maria Vinas
    Visual Optics & Biophotonics Lab, Instituto de Optica, CSIC, Madrid, Spain
  • Sara Aissati
    Visual Optics & Biophotonics Lab, Instituto de Optica, CSIC, Madrid, Spain
  • Ana Gonzalez-Ramos
    Visual Optics & Biophotonics Lab, Instituto de Optica, CSIC, Madrid, Spain
  • Mercedes Romero
    Visual Optics & Biophotonics Lab, Instituto de Optica, CSIC, Madrid, Spain
  • Lucie Sawides
    2EyesVision, Spain
  • Vyas Akondi
    Visual Optics & Biophotonics Lab, Instituto de Optica, CSIC, Madrid, Spain
  • enrique Gambra
    2EyesVision, Spain
  • Carlos Dorronsoro
    Visual Optics & Biophotonics Lab, Instituto de Optica, CSIC, Madrid, Spain
  • Eduardo Martinez-Enriquez
    Visual Optics & Biophotonics Lab, Instituto de Optica, CSIC, Madrid, Spain
  • Thomas Karkkainen,
    Research & Development, Johnson & Johnson Vision, Inc.,, Jacksonville, FL, USA, Florida, United States
  • Derek Nankivil
    Research & Development, Johnson & Johnson Vision, Inc.,, Jacksonville, FL, USA, Florida, United States
  • Susana Marcos
    Visual Optics & Biophotonics Lab, Instituto de Optica, CSIC, Madrid, Spain
  • Footnotes
    Commercial Relationships   Maria Vinas, 2EyesVision (I), Johnson & Johnson Vision Care Inc. (F); Sara Aissati, Johnson & Johnson Vision Care Inc. (F); Ana Gonzalez-Ramos, Johnson & Johnson Vision Care Inc. (F); Mercedes Romero, Johnson & Johnson Vision Care Inc. (F); Lucie Sawides, 2EyesVision (I), 2EyesVision (E), Johnson & Johnson Vision Care Inc. (F); Vyas Akondi, 2EyesVision (I), Johnson & Johnson Vision Care Inc. (F); enrique Gambra, 2EyesVision (I), 2EyesVision (E), Johnson & Johnson Vision Care Inc. (F); Carlos Dorronsoro, 2EyesVision (I), Johnson & Johnson Vision Care Inc. (F), PCT/ES2010/070218 (P200930055). Priority date: 08/04/2009 PCT/2014ES/070725 (P201331436). Priority date: 01/10/2013 P201730854. Priority date: 01/09/2017 P201531397. Priority date: 31/10/2015 (P); Eduardo Martinez-Enriquez, Johnson & Johnson Vision Care Inc. (F); Thomas Karkkainen,, Johnson & Johnson Vision Care Inc. (E), Johnson & Johnson Vision Care Inc. (I), Johnson & Johnson Vision Care Inc. (R); Derek Nankivil, Johnson & Johnson Vision Care Inc. (E), Johnson & Johnson Vision Care Inc. (I), Johnson & Johnson Vision Care Inc. (R); Susana Marcos, 2EyesVision (I), Johnson & Johnson Vision Care Inc. (F), PCT/ES2010/070218 (P200930055). Priority date: 08/04/2009 PCT/2014ES/070725 (P201331436). Priority date: 01/10/2013 P201730854. Priority date: 01/09/2017 P201531397. Priority date: 31/10/2015 (P)
  • Footnotes
    Support  European Research Council ERC-2011-AdG-294099; Spanish Government: FIS2017-84753-R, PTQ-15-07432, and ISCIII DTS16/00127; Spanish Goverment predoctoral program FPU16/01944; Collaborative agreement with Johnson & Johnson Vision, Inc., Jacksonville, FL, USA ;
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6468. doi:https://doi.org/
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    • Get Citation

      Maria Vinas, Sara Aissati, Ana Gonzalez-Ramos, Mercedes Romero, Lucie Sawides, Vyas Akondi, enrique Gambra, Carlos Dorronsoro, Eduardo Martinez-Enriquez, Thomas Karkkainen,, Derek Nankivil, Susana Marcos; Optical and visual quality with physical and visually simulated presbyopic multifocal contact lenses. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6468. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Evaluate through-focus (TF) visual and optical quality in patients with multifocal contact lenses (M-CLs) and with the corresponding simulated multifocal patterns using an adaptive optics (AO) visual simulator.

Methods : TF optical and visual quality with a center-near aspheric M-CL (Add:Low,+1.25D;Mid,+1.75D;High,+2.50D) were evaluated. A custom-developed AO visual simulator was used to measure ocular aberrations (Hartmann-Shack,ImagineEyes) and to simulate the multifocal patterns (SimVis,tunable lens working on temporal multiplexing mode). On bench TF optical quality of SimVis-simulated M-CLs (SimVis-L) was obtained from double-pass (DP) images & images of an E-stimulus using artificial eyes. Ten subjects (-3.44±0.85D; 52.3±5.21yrs) were fit with M-CL. Visual acuity (VA)&DP retinal images were measured TF in a 4-D range with the M-CL on eye, and SimVis-L.TF optical quality was also calculated from the measured aberrations.Control measurements were performed with monofocal correction. Depth-of-focus (DOF) was estimated for each condition from the width of the TF optical performance curves. The similarity of TF optical & visual performance between real M-CL&SimVis-L was assessed by the RMS (root mean square) TF difference.TF difference.Quantitative anterior segment 3-D OCT measurements were performed with/without the M-CL.

Results : OCT-based corneal elevation maps indicate minimal wrapping of the CL on eye.DOF increased with add power (E-stimuli: L2.0D<M2.4D<H3.1D; DP:L1.6D<M2.1D<H2.7D).Average VA far/near was 0/+0.3 (M-CL), 0/+0.4 (SimVis-L) & -0.1/+0.7 (Monofocal). VA remained >+0.2 in a range >3.0D with M-CL/SimVis-L, and <2D for the monofocal lens.TF DP&VA curves with M-CLs and SimVis-L on patients showed no significant differences (mixed model analysis p=0.504), with low RMS TF differences (L:0.10±0.01,M:0.07±0.02, H:0.10±0.02). While TF performance with both M-CL&SimVis-L was primarily driven by the multifocal pattern, the patient’s aberrations also played a role in visual performance with the M-CL.The predicted change in VS from monofocal to multifocal optics is positively correlated with native RMS wavefront error (r=0.713).

Conclusions : M-CLs theoretically and effectively expand DOF. SimVis-L captured the through-focus visual performance of the M-CL in most of the patients. Visual simulators may permit patients to experience vision with multifocal lenses prior to testing them on-eye.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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