July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Incidence of Corneal Dystrophy and Degeneration in a Large Ocular Pathology Centre: A 10 Year Analysis
Author Affiliations & Notes
  • Ayman Aljohani
    The MUHC-McGill University Ocular Pathology & Translational Research Laboratory, Montreal, Quebec, Canada
  • Sabrina Bergeron
    The MUHC-McGill University Ocular Pathology & Translational Research Laboratory, Montreal, Quebec, Canada
  • Thiago Carvalho e Silva Figueiredo
    The MUHC-McGill University Ocular Pathology & Translational Research Laboratory, Montreal, Quebec, Canada
  • Devinder Cheema
    The MUHC-McGill University Ocular Pathology & Translational Research Laboratory, Montreal, Quebec, Canada
  • Christina Mastromonaco
    The MUHC-McGill University Ocular Pathology & Translational Research Laboratory, Montreal, Quebec, Canada
  • Miguel N Burnier
    The MUHC-McGill University Ocular Pathology & Translational Research Laboratory, Montreal, Quebec, Canada
  • Footnotes
    Commercial Relationships   Ayman Aljohani, None; Sabrina Bergeron, None; Thiago Figueiredo, None; Devinder Cheema, None; Christina Mastromonaco, None; Miguel Burnier, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6499. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ayman Aljohani, Sabrina Bergeron, Thiago Carvalho e Silva Figueiredo, Devinder Cheema, Christina Mastromonaco, Miguel N Burnier; Incidence of Corneal Dystrophy and Degeneration in a Large Ocular Pathology Centre: A 10 Year Analysis. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6499.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Corneal dystrophy and degeneration are common in clinical practice. Correct diagnosis of dystrophies is important prior to planning the optimal treatment. The incidence and classification of the different corneal dystrophies vary depending on genetic background of the population and geographic location. The purpose of this study is to highlight the prevalence and incidence of corneal dystrophy/degeneration and the diagnostic histopathological features to differentiate the different types of corneal dystrophy.

Methods : A single-centre, retrospective analysis of 865 corneal specimens received between 2006-2017 was performed at the MUHC-McGill University Ocular Pathology & Translational Research Laboratory. Of the 865 corneal specimens, 380 (43%) were inflammatory disease, 267 (30%) corneal dystrophies and degenerations, 141 (16%) failed graft corneas, 51 (6%) viral or microorganism infections, and 26 (3%) miscellaneous diagnoses. Specimens were sorted by diagnosis and grouped by age and sex.

Results : Corneal dystrophies and degenerations represented 30% (n=267) of all corneal specimens with a slight predominance in men (n=152) when compared to women (n=115). Of these, 174 were degenerative corneal diseases, including keratoconus (37%, n=99), bullous keratopathy (22%, n=59), Salzmann nodule (3.7%, n=10), and band keratopathy (2.2%, n=6). Of the 93 corneal dystrophies, there were 48 cases (17%) of Fuch’s endothelial dystrophies, 27 cases (10.1%) of stromal dystrophies, 4 cases (1.5%) of epithelial dystrophies, and 14 cases (5.2%) of other dystrophies. Stromal dystrophies presented as lattice dystrophy in 13 patients (4.8%), granular in 4 patients (1.4%), macular in 2 patients (0.7%), and combined in 7 patients (2.6%).

Conclusions : Corneal dystrophies and degenerations represent the second most common diagnosis for corneal transplants after corneal inflammatory disease. In this Canadian large series, Fuch’s endothelial dystrophy was the most frequent, followed by corneal stromal dystrophies. Lattice stromal dystrophy was the most common type, followed by combined-Avellino stromal dystrophy. Histopathological findings are essential to characterize corneal dystrophies and degenerations. Clinicopathological correlation of corneal dystrophies enables better management of these lesions.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×