July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Corneal perforations related to rheumatoid arthritis
Author Affiliations & Notes
  • Juan Carlos Serna-Ojeda
    Instituto de Oftalmologia Conde de Valenciana, Mexico
    Ophthalmology, Banco de Ojos y Tejidos de Aguascalientes, Aguascalientes, Mexico
  • Carolina Cantu-Rosales
    Instituto de Oftalmologia Conde de Valenciana, Mexico
  • Luis Felipe Flores-Suárez
    Instituto Nacional de Enfermedades Respiratorias, Mexico
  • Enrique O Graue-Hernandez
    Instituto de Oftalmologia Conde de Valenciana, Mexico
  • Footnotes
    Commercial Relationships   Juan Carlos Serna-Ojeda, None; Carolina Cantu-Rosales, None; Luis Felipe Flores-Suárez, None; Enrique Graue-Hernandez, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6507. doi:
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    • Get Citation

      Juan Carlos Serna-Ojeda, Carolina Cantu-Rosales, Luis Felipe Flores-Suárez, Enrique O Graue-Hernandez; Corneal perforations related to rheumatoid arthritis. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6507.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To evaluate the clinical characteristics, treatment and outcomes of corneal perforations related to rheumatoid arthritis.

Methods : We retrospectively analyzed the data of 10 years from a large cohort of patients in a large reference center in Mexico City. Different variables were analyzed through a multiple logistic regression analysis for the probability to have a second procedure.

Results : Sixty eyes of 51 patients were included with an average follow-up of 27 months. The most frequent perforation zones were central and paracentral. In a multiple logistic regression analysis, in patients treated with both an initial cyanoacrylate patch and those with a penetrating keratoplasty represented an increased probability of requiring a subsequent procedure. The most frequent complication was persistent epithelial defect in 40 eyes. Most of the patients had a combination of systemic steroid and immunosuppressive therapy.

Conclusions : Corneal perforations related to rheumatoid arthritis generally require multiple interventions and a multidisciplinary approach.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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