July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Retinopathy of Prematurity screening criteria based on the ROPE-SOS trial in India
Nita Valikodath; Robison Vernon Paul Chan; Flavius Beca; Mohammed Mowafak Rami Allaham; Emily Cole; Joelle Hallak; J. Peter Campbell; Michael F Chiang; Parag Shah; Narendran Venkatapathy
Author Affiliations & Notes
  • Nita Valikodath
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, United States
    Center for Global Health, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States
  • Robison Vernon Paul Chan
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, United States
    Center for Global Health, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States
  • Flavius Beca
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, United States
    Center for Global Health, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States
  • Mohammed Mowafak Rami Allaham
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, United States
    Center for Global Health, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States
  • Emily Cole
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, United States
    Center for Global Health, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States
  • Joelle Hallak
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, United States
    Center for Global Health, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States
  • J. Peter Campbell
    Department of Ophthalmology, Oregon Health and Sciences University Hospital, Portland, Oregon, United States
  • Michael F Chiang
    Department of Ophthalmology, Oregon Health and Sciences University Hospital, Portland, Oregon, United States
  • Parag Shah
    Department of Ophthalmology, Aravind Eye Institute, Tamil Nadu, India
  • Narendran Venkatapathy
    Department of Ophthalmology, Aravind Eye Institute, Tamil Nadu, India
  • Footnotes
    Commercial Relationships   Nita Valikodath, None; Robison Chan, Visunex Medical Systems (C); Flavius Beca, None; Mohammed Mowafak Rami Allaham, None; Emily Cole, None; Joelle Hallak, None; J. Peter Campbell, None; Michael Chiang, Clarity Medical Systems (S), Inteleretina, LLC (I), Novartis (C); Parag Shah, None; Narendran Venkatapathy, None
  • Footnotes
    Support  R01EY19474, K12EY27720, P30EY10572, P30 EY001792 from the National Institutes of Health (Bethesda, MD); by grants SCH-1622679, SCH- 1622542, and SCH-1622536 from the National Science Foundation (Arlington, VA), and unrestricted departmental funding from Research to Prevent Blindness (New York, NY
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6522. doi:
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      Nita Valikodath, Robison Vernon Paul Chan, Flavius Beca, Mohammed Mowafak Rami Allaham, Emily Cole, Joelle Hallak, J. Peter Campbell, Michael F Chiang, Parag Shah, Narendran Venkatapathy; Retinopathy of Prematurity screening criteria based on the ROPE-SOS trial in India. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6522.

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Abstract

Purpose : Retinopathy of Prematurity (ROP) is a leading cause of blindness worldwide. Little is known regarding international cutoffs for birth weight (BW) and gestational age (GA) and risk and severity of ROP. Prior work from our group had characterized the BW and GA from a subset of patients from the Retinopathy of Prematurity Eradication – Save Our Sight (ROPE-SOS) trial. The purpose of this study is to categorize infants based on category of ROP and factors influencing this to describe potential ROP screening criteria.

Methods : ROPE-SOS, a mobile ROP tele-screening team performed screening examinations though digital retinal images using RetCam Shuttle (Natus Medical Incorporated, Pleasanton, CA) and indirect ophthalmoscopy. Images of each eye were reviewed by a remote ROP expert at Aravind Eye Hospital and evaluated for presence of ROP, zone, stage, plus disease, and aggressive posterior ROP (APROP). Other factors that were recorded include BW, GA, and treatment. Frequencies and means will be calculated for these variables. Using the International Classification for Retinopathy of Prematurity and the Early Treatment for Retinopathy of Prematurity Study, category of ROP will be determined. Relative risk analyses will be conducted.

Results : A total of 3622 new patients were seen. An additional 2799 return visits were recorded. Of those screened, average BW was 1647.47 grams and average GA was 32.83 weeks. We will report infants who developed any ROP and APROP. We will specifically report infants who had Type 2 or worse ROP. Relative risks of developing any ROP and type 2 or worse ROP based on BW and GA will be reported.

Conclusions : The average birth weight and gestational age for infants in this study was higher than what is reported in the literature for infants with ROP in the USA. We will characterize category of ROP in this group and the relative risk of developing any ROP or Type 2 or worse ROP which will potentially provide information about screening criteria for infants with ROP in India.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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