July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Optical coherence tomography evaluation of early foveal structural changes after anti-VEGF treatment for type 1 ROP.
Author Affiliations & Notes
  • Giulia Maria Amorelli
    Catholic University of Sacred Heart - Rome, Gaeta, Italy
  • Lorenzo Orazi
    Polo Nazionale Riabilitazione visiva - IAPB Italia Onlus, Rome, Italy
  • Costanza Barresi
    Catholic University of Sacred Heart - Rome, Gaeta, Italy
  • Fernando Molle
    Catholic University of Sacred Heart - Rome, Gaeta, Italy
  • Domenico Lepore
    Catholic University of Sacred Heart - Rome, Gaeta, Italy
  • Footnotes
    Commercial Relationships   Giulia Maria Amorelli, None; Lorenzo Orazi, None; Costanza Barresi, None; Fernando Molle, None; Domenico Lepore, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6534. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Giulia Maria Amorelli, Lorenzo Orazi, Costanza Barresi, Fernando Molle, Domenico Lepore; Optical coherence tomography evaluation of early foveal structural changes after anti-VEGF treatment for type 1 ROP.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6534.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To determine the morphological changes of foveal structures before and after treatment with anti-VEGF in premature infants with type 1 retinopathy of prematurity imaged with hand-held SD-OCT (Bioptigen, Inc).

Methods : Imaging with handheld SDOCT (Bioptigen, Inc) was performed at the bedside in 14 non-sedated premature infants with type 1 retinopathy of prematurity. Mean GA was 25,4 weeks and mean BW was 682,91 grams. Mean PCA was 37,6 weeks at the time of injection. All children were image before treatment, 1 week and 1 month after anti-VEGF. Presence or absence of cystoid macular changes and staging of CME was determined (INL cysts or CME). Central foveal thickness (CFT), nasal parafoveal inner (nIRT) and outer (nORT) and temporal parafoveal inner (tIRT) and outer retinal thicknesses (tORT) were measured.

Results : 14 eyes of 7 premature babies (58,3%) showed bilateral cystoid macular changes at the time of first examination (28% showed INL cysts, 72% showed evident CME) with a mean CFT of 227,29 µm. 10 eyes of 5 babies (41%) did not show any foveal abnormalities. Mean nIRT, nORT, tIRT an tORT were 173,45 µm, 80,13 µm, 167,25 µm and 80,34 µm, respectively. At 1 week follow-up after anti-VEGF injection, 4 eyes of 2 babies showed appearance of macular edema and increased mean CFT (317 µm). 6 eyes of 3 babies with preexisting CME showed enlarged cystic spaces, while all other babies were stable. After 1 month, 18 eyes of 9 patients showed persistent distortion of foveal morphology with cystoid macular edema.

Conclusions : Cystoid macular changes showed not to be related to anti-VEGF treatment in preterm babies. Further studies with larger figures and longer follow up will help to understand the correlation between OCT findings and their evolution with anti-VEGF treatment for type 1 ROP.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×