July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Contrast sensitivity in patients with Vogt-Koyanagi-Harada disease
Author Affiliations & Notes
  • Yumi Hasegawa
    Tsukuba University, Tsukuba, Ibaraki, Japan
  • Fumiki Okamoto
    Tsukuba University, Tsukuba, Ibaraki, Japan
  • Tetsuro Oshika
    Tsukuba University, Tsukuba, Ibaraki, Japan
  • Footnotes
    Commercial Relationships   Yumi Hasegawa, Jhonson & Jhonson vision (R), Nikon (R), Santen (R), Senju (R); Fumiki Okamoto, Alconphama (F), Nidek (F), Pfizer (F), Santen (F), Tsukuba University (P); Tetsuro Oshika, Alcon (F), Alcon (C), HOYA (F), HOYA (C), Jhonson & Jhonson Vision (F), Jhonson & Jhonson Vision (C), Kai (F), Kowa (F), Mitsubishi Tanabe (F), Novartis (F), Otsuka (F), Pfizer (F), Santen (F), Santen (C), Senju (F), Tomey (F), Topcon (F)
  • Footnotes
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Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6663. doi:
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    • Get Citation

      Yumi Hasegawa, Fumiki Okamoto, Tetsuro Oshika; Contrast sensitivity in patients with Vogt-Koyanagi-Harada disease. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6663.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To assess contrast sensitivity in patients with resolved Vogt-Koyanagi-Harada disease (VKH).

Methods : This study included 22 patients with VKH who were considered to have stable visual function for at least 6 months or more after steroid pulse treatment (42.8 ± 12.4 [mean ± SD] years). Decimal visual acuity of all subjects was 1.0 (logMAR 0) or better. We examined contrast sensitivity at 4 spatial frequencies (3, 6, 12, 18 cycles/degree) using the CSV-1000E (Vector Vision). From the data obtained with the CSV-1000E, the area under the log contrast sensitivity function (AULCSF) was calculated. Age-matched 47 normal subjects (43.4 ± 12.1 years) were also included. Clinical information including age, visual acuity before treatment, duration of disease, presence of macular retinal detachment (RD), presence of pigment epithelium undulation, central foveal thickness, interval from initiation of therapy to RD resolved, recurrence of VKH, development of cystoid macular edema, epiretinal membrane and sunset glow fundus were recorded.

Results : Contrast sensitivitywas significantly worse in eyes with VKH than in normal controls at high spatial frequencies (12, 18 cycles/degree). Decreased AULCSF was significantly associated with longer duration of disease (p = 0.0007) and development of epiretinal membrane (p = 0.018) in eyes with VKH.

Conclusions : Even in eyes with VKH which have good visual acuity by treatment, contrast sensitivity at high spatial frequencies decreased. Decreased contrast sensitivity was related to longer duration of disease and development of epiretinal membrane.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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