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Yumi Hasegawa, Fumiki Okamoto, Tetsuro Oshika; Contrast sensitivity in patients with Vogt-Koyanagi-Harada disease. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6663.
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To assess contrast sensitivity in patients with resolved Vogt-Koyanagi-Harada disease (VKH).
This study included 22 patients with VKH who were considered to have stable visual function for at least 6 months or more after steroid pulse treatment (42.8 ± 12.4 [mean ± SD] years). Decimal visual acuity of all subjects was 1.0 (logMAR 0) or better. We examined contrast sensitivity at 4 spatial frequencies (3, 6, 12, 18 cycles/degree) using the CSV-1000E (Vector Vision). From the data obtained with the CSV-1000E, the area under the log contrast sensitivity function (AULCSF) was calculated. Age-matched 47 normal subjects (43.4 ± 12.1 years) were also included. Clinical information including age, visual acuity before treatment, duration of disease, presence of macular retinal detachment (RD), presence of pigment epithelium undulation, central foveal thickness, interval from initiation of therapy to RD resolved, recurrence of VKH, development of cystoid macular edema, epiretinal membrane and sunset glow fundus were recorded.
Contrast sensitivitywas significantly worse in eyes with VKH than in normal controls at high spatial frequencies (12, 18 cycles/degree). Decreased AULCSF was significantly associated with longer duration of disease (p = 0.0007) and development of epiretinal membrane (p = 0.018) in eyes with VKH.
Even in eyes with VKH which have good visual acuity by treatment, contrast sensitivity at high spatial frequencies decreased. Decreased contrast sensitivity was related to longer duration of disease and development of epiretinal membrane.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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