July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Comparison of unilateral granulomatous anterior uveitis by causative diseases
Author Affiliations & Notes
  • Haruna Shimazaki
    Ophthalmology, National Defense Medical College, Tokorozawa-Shi, Saitama-Ken, Japan
  • Kei Takayama
    Ophthalmology, National Defense Medical College, Tokorozawa-Shi, Saitama-Ken, Japan
  • Shimpei Sugaoka
    Ophthalmology, National Defense Medical College, Tokorozawa-Shi, Saitama-Ken, Japan
  • Masaru Takeuchi
    Ophthalmology, National Defense Medical College, Tokorozawa-Shi, Saitama-Ken, Japan
  • Footnotes
    Commercial Relationships   Haruna Shimazaki, None; Kei Takayama, None; Shimpei Sugaoka, None; Masaru Takeuchi, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6681. doi:
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      Haruna Shimazaki, Kei Takayama, Shimpei Sugaoka, Masaru Takeuchi; Comparison of unilateral granulomatous anterior uveitis by causative diseases. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6681.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the differences of clinical findings in Posner-Schlossman syndrome (P-S), herpes simplex virus-associated anterior uveitis (HSV-AU), varicella zoster virus-associated anterior uveitis (VZV-AU), and cytomegalovirus-associated anterior uveitis (CMV-AU).

Methods : Medical records of 10 patients of P-S, 12 patients of HSV-AU, 24 patients of VZV-AU, and 5 patients of CMV-AU between April 2010 to October 2018 were retrospectively reviewed. HSV-AU, VZV-AU, and CMV-AU were diagnosed by polymerase chain reaction test (PCR) using anterior aqueous humor and P-S was determined by the typical clinical findings and course and negative results for PCR. Age of the onset, sex, intraocular pressure (IOP) and best corrected visual acuity (BCVA) converted logMAR in the acute and remission phase, positive rates of keratic participants (KP) and iris nodule, disease duration in the first episode were compared.

Results : There was no significant difference in age at the onset, sex, and positive rates of KP and iris nodule between them. The intraocular pressure in the acute and remission phase was 23.3 ± 9.6 (14-43) and 12.6 ± 2.5 (9-18) mmHg in P-S, 19.1 ± 11.2 (8.3-50.5) and 13.8 ± 4.3 (3.3-19.0) mmHg in HSV-AU, 20.0 ± 7.7 (9-40) and 13.9 ± 4.1 (9-26) mmHg in VZV-AU, and 23.6 ± 14.0 (11-50) and 18.6 ± 5.6 (12-26) mmHg in CMV-AU respectively, and statistical difference was also not observed between them. logMAR in the acute and remission phase was -0.012 ± 0.17 (-0.18 - 0.22) and -0.046 ± 0.089 (-0.18 - 0.15) in P-S group, 0.50 ± 0.58 (-0.18 - 2.0) and 0.054 ± 0.26 (-0.18 - 0.52) in HSV-AU group, 0.54 ± 0.84 (-0.18 – 3.0) and 0.091 ± 0.31 (-0.18 - 1.05) in VZV-AU group, and 0.73 ± 0.50 (0.046 - 1.4) and 1.5 ± 1.7 (0 – 4.0) in CMV-AU group respectively, and logMAR in the acute phase of P-S group was significantly more preferable than HSV-AU group (P = 0.0213) or CMV-AU group (P = 0.0381). The disease duration was 15 ± 11 (3 - 41) days in P-S group, 115 ± 152 (7 - 583) days in HSV-AU, 40 ± 28 (7 - 105) days in VZV-AU, and 48 ± 45 (18 - 126) days in CMV-AU, and the disease duration of P-S group was significantly shorter than HSV group (P = 0.0124) or VZV group (P = 0.0086).

Conclusions : These results indicate that in P-S, visual acuity during the acute phase is more preserved and the disease duration is shorten compared with herpes-associated acute anterior uveitis.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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