July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
A Forty Years Follow-Up Study of Patients with Uveitis Associated with Juvenile Idiopathic Arthritis (JIA).
Author Affiliations & Notes
  • Angelika Skarin
    Department of Clinical Sciences Lund, Opthalmology Lund, Sweden, Lund University, Skåne University Hospital, Lund, Sweden
  • Ola Rauer
    Department of Clinical Sciences Lund, Opthalmology Lund, Sweden, Lund University, Skåne University Hospital, Lund, Sweden
  • Elisabeth Bengtsson-Stigmar
    Department of Clinical Sciences Lund, Opthalmology Lund, Sweden, Lund University, Skåne University Hospital, Lund, Sweden
  • Footnotes
    Commercial Relationships   Angelika Skarin, None; Ola Rauer, None; Elisabeth Bengtsson-Stigmar, None
  • Footnotes
    Support  STIFTELSEN FÖR SYNSKADADE I FD MALMÖHUS LÄN, SWEDEN, SÖDRA SJUKVÅRDSREGIONEN, SWEDEM
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6685. doi:
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    • Get Citation

      Angelika Skarin, Ola Rauer, Elisabeth Bengtsson-Stigmar; A Forty Years Follow-Up Study of Patients with Uveitis Associated with Juvenile Idiopathic Arthritis (JIA).. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6685.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : A cohort of patients with JIA-associated uveitis were seen at the Child Rheumatology section of the Rheumatology Clinic, University Hospital of Lund, Sweden, between 1973 and 1982. Out of a total of 350 consecutive patients with JIA, 55 developed uveitis (15.7%). A 7- and 24-years follow-up has previously been published of this patient group with uveitis. Now a 40-year follow-up has been performed on the same kohort.

Methods : Ophthalmic charts concerning the latest 3 year were examined.

Results : Eleven (20%) patients had died prior to the present follow-up. The causes of death has not yet been investigated. Thirty patients were willing to participate in this follow-up. The mean age of the participants were 47 years. The joint disease had started with a mean of 43 years earlier and uveitis had started with a mean of 41 years earlier. In the original cohort 32 (64%) patients were female and 21 (38%) were male. In the present follow-up 16 (53%) were female and 14 (47%) male. Thirteen patients (24% of the original cohort) still had active uveitis. Of the original 55 patients a total of 14 eyes had developed visual acuity (VA) < 20/200 after 40 years (12%). Four patients had VA < 20/200 in the best eye after 40 years (13%). Of the participating 30 patients 70% had developed cataract and 40% had glaucoma. Of the original cohort (55 patients) 49% had developed cataract and 29% had developed glaucoma 40 years after start of their uveitis.

Conclusions : The presence of active uveitis and increasing prevalence of cataract and glaucoma compared to our 24 years follow-up indicates a future risk for increased visual impairment. These data are unique and can be valuable as a comparison to future long term studies of this group of patients treated with the present, probably more efficient, treatment regimes.
That 20% of this cohort died before the age of 50 is striking and will be further investigation.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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