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Jacqueline Tan, Tianni Jia, Roslyn Liao, Fiona Stapleton; The effect of Manuka eye drops on tear film properties. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6739.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effects of Manuka (Leptospermum sp. honey) eye drops versus a conventional non-lipid based eye drop on tear film properties in symptomatic dry eye subjects after 28 days of treatment.
Forty-six subjects with symptoms of dry eye (Ocular Surface Disease Index [OSDI] score >12) were enrolled and randomly assigned to receive either the test Manuka (Melcare Biomedical, Australia) or control non-lipid based lubricant (Alcon, USA) eye drops in this double-masked study (NCT03622619). Lipid layer thickness (LLT; Lipiview II, TearScience), tear film evaporation rate (TER; Vapometer, Delfin Technologies), fluorescein tear film break-up time (TBUT) and subjective symptoms scores (OSDI) and visual analogue scales (VAS) for burning/stinging, grittiness/foreign body sensation, dryness, blurry vision and overall discomfort were measured before and after 28 days of instilling the eye drops three times daily. Independent t-tests or Mann Whitney U tests were used to compare the two groups.
Forty-two subjects completed the study: 21 subjects (9 males and 12 females) with average age 22.2 ± 3.5 years in the test group, and 21 subjects (5 males and 16 females) with average age 20.6 ± 3.2 years in the control group. After 28 days of treatment, TER showed a significantly greater reduction in the test group compared to the control group (-10.8 ± 16.8 vs. 0.7 ± 10.8 gm-2h, p = 0.01). TBUT tended to increase in the test group compared to the control group (2.0 ± 3.0 vs. 0.0 ± 3.1 sec, p = 0.06), and a significantly greater reduction (improvement) in OSDI scores was observed in the test group compared to the control group (-19.6 ± 10.9 vs. -10.7 ± 7.1, p = 0.01). No significant differences were found between the two groups for LLT and any of the VAS scores.
The Manuka eye drops were more effective for reducing TER, increasing TBUT and improving symptoms of dry eye compared to the conventional non-lipid based eye drops after 28 days of daily use.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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