July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Evaluation of tear film osmolarity using Tearlab® and I-Pen® osmometry
Author Affiliations & Notes
  • Elisabeth M Messmer
    Dept. Ophthalmology, LMU, Ludwig Maximilians University, Munich, Germany
  • Markus M. Schaumberger
    Dept. Ophthalmology, LMU, Ludwig Maximilians University, Munich, Germany
  • Siegfried Priglinger
    Dept. Ophthalmology, LMU, Ludwig Maximilians University, Munich, Germany
  • Susanna F. Koenig
    Dept. Ophthalmology, LMU, Ludwig Maximilians University, Munich, Germany
  • Footnotes
    Commercial Relationships   Elisabeth Messmer, Alcon/Novartis (C), Bayer (C), Dompé (C), Pharm-Allergan (C), Santen (C), Shire (C), Thea (C), TRB-Chemedica (C), Ursapharm (F), Visufarma (C); Markus Schaumberger, None; Siegfried Priglinger, None; Susanna Koenig, None
  • Footnotes
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Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6773. doi:
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    • Get Citation

      Elisabeth M Messmer, Markus M. Schaumberger, Siegfried Priglinger, Susanna F. Koenig; Evaluation of tear film osmolarity using Tearlab® and I-Pen® osmometry. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6773.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare tear film osmolarities in normal individuals as measured by Tearlab® and I-Pen® osmometers.

Methods : 51 healthy subjects (mean age 40.6 years, range 17-63 years, 66.7% females) without dry eye disease (Ocular surface disease index < 13, tear film break up time > 7 seconds, normal Schirmer-test > 10 mm/5 minutes) were included in this study. Tear film osmolarity was measured in the tear meniscus (Tearlab®) and in the palpebral conjunctiva (I-Pen®) with a 30-minute interval. Statistical analysis was performed using Wilcoxon tests and Spearman correlations.

Results : Mean Tearlab® osmolarities were 295.1 mOsm/l (right eye), 294.0 mOsm/l (left eye), and 294.6 mOsm/l (mean of both eyes) with a range of 268 to 394 mOsm/l. I-Pen® measured mean osmolarites of 301.6 mOsm/l (right eye), 302.5 mOsm/l (left eye), and 302.1 mOsm/l (mean of both eyes) with a range of 268 to 394 mOsm/l. There was a significant difference in tear film osmolarities for the two techniques for both single eyes (p<0.02) and the mean value of both eyes (p<0.001). Tearlab® and I-Pen® measurements did not correlate significantly in any eye (r=0.27 and r=0.08 for right and left eye, accordingly). When considering a cut-off value of 308 mOsm/l (as suggested for Tearlab®), 98.0% of Tearlab® values and 68.6% of I-Pen® values were located in the normal range.

Conclusions : I-Pen® measured significantly higher tear film osmolarities than Tearlab®. The location of the measurement site in the palpebral conjunctiva could be responsible for this difference. Our preliminary results indicate that higher cut-off values between 316 and 320 mOsm/l should be considered when using I-Pen® for evaluation of tear film osmolarity.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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