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Nallely Rubi Morales-Mancillas, Julio C Hernandez, Gabriela Castrejón-Perez, Jorge E Valdez; Correlation between ocular surface disease index and dry eye functional parameters using a non-invasive method. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6797.
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© ARVO (1962-2015); The Authors (2016-present)
The dry eye is a multifactorial disease of the tears and the ocular surface with usually poor correlation of its symptoms and several clinical tests. A retrospective clinical study was performed to analyze clinical parameters (meibomian gland function, tear film, and bulbar redness) in dry eye patients using a Keratograh 5M. A correlation with the ocular surface disease index (OSDI) was performed.
The study was conducted in the Institute of Ophthalmology at the Zambrano Hellion Medical Center / Tecnológico de Monterrey between January 2018 and October 2018. Patients with dry eye with ages 20-80 years were selected. A retrospective study was performed. Using the OCULUS Keratograph® 5 M several clinical parameters were analyzed: tear meniscus height (TMH), noninvasive first tear break-up time (NIBUT-Fir), conjunctivochalasis, infrared meibography, and hyperemia. All subjects eye symptoms were assessed using the ocular surface disease index (OSDI).
A total of 83 patients (n=166 eyes) with mean age of 49.4 ± 16 years and female predominance (78.04%) were enrolled. Using the OSDI score, 6 patients (7.31%) were asymptomatic, 35 (42.68%) showed mild surface symptoms, 31 (37.80%) reported moderate surface symptoms, and 10 (12.19%) exhibited severe surface symptoms. The mean OSDI score was 23.26 ± 17.51. OSDI score showed a significant correlation with TMH (r=-0.328 P 0.001), conjunctivochalasis (r=0.155 P 0.028), and meibography (r=0.150 P 0.033). A positive correlation was observed between age and meibography (r=0.255 P 0.001), conjunctivochalasis (r=0.300 P 0.001), and TMH (r= 0.306 P 0.001). Also, TMH and NIBUT-Fir showed a positive correlation (r=0.202 P 0.006). The multiple linear regression analysis showed meibography as the predictor variable that most explained the OSDI (R2adjusted =0.205, β=+0.292 P 0.012).
The Keratograph 5M is an accurate and non-invasive method that provides many features that are useful for obtaining dry eye data for patients, including meibography, NIBUT-Fir, hyperemia, and TMH. In our study the main predictors variables of OSDI were meibography and TMH. This device can be an alternative to conventional methods to evaluate tear conditions on the ocular surface.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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