July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Reverse Polarity OCT Angiography as a Biomarker of Neovascular and Ischaemic Retinal Diseases
Author Affiliations & Notes
  • Chris Ashton
    NHS, London, United Kingdom
  • Nishal Patel
    NHS, London, United Kingdom
  • Footnotes
    Commercial Relationships   Chris Ashton, None; Nishal Patel, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3045. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Chris Ashton, Nishal Patel; Reverse Polarity OCT Angiography as a Biomarker of Neovascular and Ischaemic Retinal Diseases. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3045.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Neovascular and proliferative diseases such as Wet Age Related Macular Degeneration, Diabetic retinopathy and Retinal Vein Occlusion have been treated successfully over the preceding years following diagnosis with SD-OCT and FFA imaging. OCT Angiography has the ability to produce rapid non-invasive anatomical and physiological assessment of vasculature that changes in these disease processes. Our intention was to use novel imaging processes with Swept Source OCTA using flow indices as a biomarker for disease progression and regression following appropriate therapy.

Methods : A retrospective case series of retinal patients (n=24) with choriodal or retinal neovascularization at different stages of pathology underwent consecutive OCTA imaging using Swept source TopCon Triton OCTA device at baseline and after Anti-VEGF Injection/ laser therapy. Image analysis of Flow Density maps was performed with reverse polarization using Imagenet 6 software and zero modification of images or segmentation of OCTA images.

Results : Active Choroidal neovascular complexes are visible clearly (in red) and inactive lesions have a reduction in size and intensity in the avascular reverse Polarity OCTA flow density maps following therapy. In the superficial plexus, active complexes (in red) due to chronic retinal ischaemia are clearly visible whereas deeper plexus flow density maps show reduction in diseases such as DMO and Branch retinal vein occlusion.

Conclusions : Reverse polarity OCTA imaging with flow density maps at variable depths can be used as an adjunctive biomarker for neovascular and ischaemic retinal diseases at onset and following therapy. Static Quantitative measurements of flow indices at specific regions of the retina, either in the macula or periphery may be used in the future to determine therapy response and likelihood of disease recurrence to assist in early management of these conditions.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×