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Jay C Wang, Ines Lains, Rebecca Silverman, Lucia Sobrin, Demetrios Vavvas, Joan W Miller, John B Miller; Visualizing the Choriocapillaris and Choroidal Vasculature in Normal Eyes with En Face Swept-Source Optical Coherence Tomography Versus Angiography. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3051.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the visualization of the choriocapillaris and deeper choroidal vessels in normal eyes in en face swept source optical coherence tomography (SS-OCT) versus SS-OCT angiography (SS-OCTA).To compare the visualization of the choriocapillaris and deeper choroidal vessels in normal eyes in en face swept source optical coherence tomography (SS-OCT) versus SS-OCT angiography (SS-OCTA).
This is a cross-sectional study of consecutive eyes without chorioretinal disease. En face SS-OCT and SS-OCTA images of the choriocapillaris and choroid were assessed for visualization of the vasculature. Choroidal vessel densities (CVD) of the choriocapillaris, inner choroid, mid-choroid, and outer choroid were calculated from binarized en face SS-OCT and SS-OCTA images. Paired t-tests and linear regression were used for statistical analysis.
Twenty-seven eyes of twenty-seven patients were included. There was no statistically significant difference between the CVDs of the mid-choroid assessed with en face SS-OCT versus SS-OCTA (p = 0.21). However, there were statistically significant differences between the CVDs for the choriocapillaris (p < 0.001), inner choroid (p < 0.001), and outer choroid (p = 0.006). Qualitative analysis revealed incomplete visualization of vessels in the inner choroid and exaggeration of vessel lumens in the outer choroid with SS-OCTA.
Visualization of the choriocapillaris is superior with SS-OCTA, but it has numerous limitations that make visualization of deeper choroidal vessels less reliable when compared to en face SS-OCT. It is important to understand such limitations when utilizing these technologies to study the choroidal vasculature in chorioretinal disease.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
Figure 1. Representative example of image export and processing. Swept source optical coherence tomography angiography (SS-OCTA) and en face swept source optical coherence tomography (SS-OCT) images are exported from the choriocapillaris (A,I), inner choroid (B,J), mid-choroid (C,K), and outer choroid (D,L). These images are then binarized in imageJ using the Niblack local thresholding algorithm (E-H,M-P), which are used to calculate choroidal vessel density.
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