July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Effect of Body Position on IOP, Intracranial Pressure and the Translaminar Pressure Difference Measured with Continuous Wireless Telemetry in Nonhuman Primates
Author Affiliations & Notes
  • Jessica V Jasien
    Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Brian C Samuels
    Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • James M Johnston
    Neurosurgery, University of Alabama at Birmingham, Birm, Alabama, United States
  • J Crawford C Downs
    Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Footnotes
    Commercial Relationships   Jessica Jasien, None; Brian Samuels, None; James Johnston, None; J Crawford Downs, None
  • Footnotes
    Support  BrightFocus Foundation G2016165 (Downs), NIH R01 EY024732 (Downs), NIH R01 EY026035 (Downs), P30 EY003039 (PI: Pittler; UAB NEI Core Grant), EyeSight Foundation of Alabama (Unrestricted Research Funds), Research to Prevent Blindness (Unrestricted Research Funds)
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3913. doi:https://doi.org/
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    • Get Citation

      Jessica V Jasien, Brian C Samuels, James M Johnston, J Crawford C Downs; Effect of Body Position on IOP, Intracranial Pressure and the Translaminar Pressure Difference Measured with Continuous Wireless Telemetry in Nonhuman Primates. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3913. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Recent retrospective clinical studies and animal experiments have suggested that cerebrospinal fluid pressure (CSFP) is important in glaucoma and Spaceflight Associated Neuro-Ocular Syndrome (SANS) pathogenesis. Intraocular pressure (IOP) and CSFP are the driving components of translaminar pressure difference (TLPD=IOP-CSFP), which directly affects the optic nerve head and contained lamina cribrosa. The lack of continuous and accurate CSFP measurement has impeded research into the role of TLPD in glaucoma and SANS.

Methods : We have developed an implantable pressure telemetry system based on a small piezoelectric sensor with low drift. Unilateral IOP is measured from the anterior chamber, intracranial pressure (ICP, a surrogate measure of CSFP) is measured in the brain parenchyma, and arterial blood pressure (BP) is measured in the femoral artery. For this study, we measured physiologic pressures in four nonhuman primates (NHPs) continuously at 200Hz for 30 seconds per body position for three sessions.

Results : Data were collected in four male rhesus macaques (Figure 1) for varying body positions, with 30s of continuous pressure data averaged at each position. TLPD was quantified as IOP-ICP. Relative change of IOP (n= 2 NHPs), ICP (n=4 NHPs), and TLPD (n=2 NHPs) were compared for changes in body position: supine to prone, supine to seated, supine to standing and supine to inverted (Figure 1). Results show that relative change in ICP and TLPD changes significantly with different body positions (Figure 1), with the greatest relative changes observed when moving from supine to either the seated, (ICP -13.5±2.1 p< 0.0001 and TLPD +11.4±0.7 p< 0.01), standing (ICP -12.1±2.9 p< 0.001 and TLPD +8.6±1.5 p< 0.03) or inverted (ICP +19.7±0.9 p< 0.001 and TLPD -8.9±4.8) positions.

Conclusions : Development of this novel NHP model with continuous telemetry of IOP, ICP and TLPD variability will allow evaluation of the hypothesis that IOP, ICP, and/or TLPD fluctuations contribute independently to glaucoma onset and/or progression, as well as to investigate the mechanisms underlying SANS.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Figure 1. Mean relative change of IOP, ICP, TLPD and AOP (mmHg) of 4 NHPs by change of body position. ( * = p< 0.01 and † = p< 0.05)

Figure 1. Mean relative change of IOP, ICP, TLPD and AOP (mmHg) of 4 NHPs by change of body position. ( * = p< 0.01 and † = p< 0.05)

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