July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Anterior Scleral Canal Opening (ASCO) offset relative to Bruch’s Membrane Opening (BMO) influences the Angular Location of Peak Retinal Nerve Fiber Layer Thickness (RNFLT) in Healthy Human Eyes
Author Affiliations & Notes
  • Seung Woo Hong
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Portland, Oregon, United States
  • Hongli Yang
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Portland, Oregon, United States
  • Stuart Keith Gardiner
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Portland, Oregon, United States
  • Haomin Luo
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Portland, Oregon, United States
  • Christy A Hardin
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Portland, Oregon, United States
  • Glen Sharpe
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Joseph Caprioli
    Jules Stein Eye Institute, Los Angeles, Oregon, United States
  • Shaban Demirel
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Portland, Oregon, United States
  • Christopher A Girkin
    Department of Ophthalmology, School of Medicine, University of Alabama at Birminham, Birmingham, Alabama, United States
  • Jeffrey M Liebmann
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York, New York, United States
  • Christian Y Mardin
    Department of Ophthalmology, University of Erlangen, Erlangen, Bavaria, Germany
  • Harry A Quigley
    Wilmer Eye Institute, Baltimore, Maryland, United States
  • Alexander F Scheuerle
    Department of Ophthalmology, University of Heidelberg, Heidelberg, Baden-Württemberg, Germany
  • Brad Fortune
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Portland, Oregon, United States
  • Balwantray C Chauhan
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Claude F Burgoyne
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Seung Woo Hong, None; Hongli Yang, None; Stuart Gardiner, None; Haomin Luo, None; Christy Hardin, None; Glen Sharpe, None; Joseph Caprioli, Heidleberg Engineering (F); Shaban Demirel, Heidleberg Engineering (F); Christopher Girkin, Heidleberg Engineering (F); Jeffrey Liebmann, Aerie Pharmaceuticals, Inc. (C), Alcon Laboratories, Inc. (C), Allergan, Inc. (C), Bauch Lomb (C), Carl Zeiss Meditech, Inc. (C), FORSIGHT Vision 5 (C), Heidelberg Engineerging (C), Heidelberg Engineering (F), Heidelberg Engineering (S), Inotek Pharmaceuticals, Inc. (C), National Eye Institute (S), Quark Pharmaceuticals, Inc. (C), Reichert, Inc. (C), SOLX, Inc. (I), Sustained Nano Systems (C); Christian Mardin, Heidleberg Engineering (F); Harry Quigley, Heidleberg Engineering (F); Alexander Scheuerle, Heidleberg Engineering (F); Brad Fortune, Inotek Pharmaceuticals (C); Balwantray Chauhan, Heidelberg Engineering (C), Heidelberg Engineering (S), Heidleberg Engineering (F); Claude Burgoyne, Heidelberg Engineering (C), Heidelberg Engineering (S), Heidleberg Engineering (F)
  • Footnotes
    Support  National Eye Institute Grant (NIH/NEI R01-EY021281), supplemental support from Legacy Good Samaritan Foundation and Heidelberg Engineering
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4740. doi:
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      Seung Woo Hong, Hongli Yang, Stuart Keith Gardiner, Haomin Luo, Christy A Hardin, Glen Sharpe, Joseph Caprioli, Shaban Demirel, Christopher A Girkin, Jeffrey M Liebmann, Christian Y Mardin, Harry A Quigley, Alexander F Scheuerle, Brad Fortune, Balwantray C Chauhan, Claude F Burgoyne; Anterior Scleral Canal Opening (ASCO) offset relative to Bruch’s Membrane Opening (BMO) influences the Angular Location of Peak Retinal Nerve Fiber Layer Thickness (RNFLT) in Healthy Human Eyes. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4740.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the effects of ASCO/BMO offset direction and magnitude on the sectoral distribution of peripapillary RNFLT and peak RNFLT location in 303 healthy mixed ethnicity eyes.

Methods : One eye of each subject underwent RNFL 12° circle scan and ONH imaging (Spectralis) (24 enhanced depth ONH radial B-scans, centered on BMO centroid and aligned to the Fovea-BMO (FoBMO) axis). For each eye, in each ONH B-scan, BMO and ASCO were manually segmented and BMO and ASCO reference planes, centroids, and area were determined. The neural canal axis was defined to be the vector connecting the BMO and ASCO centroids, (Fig 1A). ASCO/BMO offset direction and magnitude were determined by projecting the axis vector onto the BMO plane and deconstructed into multiple vector component combinations. Sectoral (30°) RNFLT and the angular location of superior and inferior peak RNFLT were determined relative to the FoBMO axis. The effect of gender, age, axial length, IOP and race/ethnicity on ASCO/BMO offset was assessed by ANOVA. Correlations between the superior-inferior and nasal-temporal components of ASCO/BMO offset direction, sectoral RNFLT and the angular difference between the superior and inferior peak RNFLT were assessed.

Results : Axial length had positive correlation to ASCO/BMO offset magnitude (P<0.001) and Caucasian and Asian and Native American Ethnicity had greater ASCO/BMO offset than Hispanic and African Ethnicity (P≤0.004). The nasal-temporal component of ASCO/BMO offset demonstrated direction-specific correlations to sectoral RNFLT, (Fig 2), (all sectors significant except inferior-temporal, P≤0.009 by linear regression, R2s ranging from 0.023 to 0.175, being highest nasal-superiorly). The superior-inferior component of ASCO/BMO offset demonstrated significant correlation only to the superior sectoral RNFLT, (P=0.023, Fig 2A). The angular difference between superior and inferior peak RNFLT negatively correlated with the nasal offset of ASCO relative to BMO (P<0.001, R2=0.088).

Conclusions : Nasal offset of the ASCO relative to BMO, is associated with rotation of the superior and inferior RNFLT peaks towards the FoBMO axis. While this rotation would be expected to diminish both the superior-nasal and inferior-nasal RNFLT, the effect is greatest within the nasal-superior sector.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

 

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