July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Longitudinal Analysis of the Bruch’s Membrane Opening Morphometrics in Glaucoma
Author Affiliations & Notes
  • Mahadev Bhalla
    University of British Columbia, British Columbia, Canada
  • Morgan Heisler
    Simon Fraser University, British Columbia, Canada
  • Sherry X. Han
    Simon Fraser University, British Columbia, Canada
  • Marinko V Sarunic
    Simon Fraser University, British Columbia, Canada
  • Mirza Faisal Beg
    Simon Fraser University, British Columbia, Canada
  • Paul Mackenzie
    University of British Columbia, British Columbia, Canada
  • Sieun Lee
    Simon Fraser University, British Columbia, Canada
  • Footnotes
    Commercial Relationships   Mahadev Bhalla, None; Morgan Heisler, None; Sherry Han, None; Marinko Sarunic, None; Mirza Beg, None; Paul Mackenzie, None; Sieun Lee, None
  • Footnotes
    Support  Michael Smith Foundation for Health Research, Natural Sciences and Engineering Research Council of Canada, Canadian Institutes of Health Research and National Health, Brain Canada
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5519. doi:
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      Mahadev Bhalla, Morgan Heisler, Sherry X. Han, Marinko V Sarunic, Mirza Faisal Beg, Paul Mackenzie, Sieun Lee; Longitudinal Analysis of the Bruch’s Membrane Opening Morphometrics in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5519.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate longitudinal changes in morphological characteristics of Bruch’s membrane opening (BMO) in control and glaucomatous subjects.

Methods : 53 myopic eyes (17 control, 6 suspect, 10 progressing glaucoma, and 20 stable glaucoma) were followed for an average of 4.2 ± 1.4 years and imaged at the baseline and two follow-up appointments using a 1060nm swept-source optical coherence tomography system. Bruch’s membrane and Bruch's membrane opening (BMO) were segmented, and four morphometric BMO parameters (area, eccentricity, planarity, depth) were measured.

Results : There was no significant changes in BMO area or eccentricity for all groups. BMO bowing, measured by BMO planarity, was shown to increase in the progressing glaucoma group (1.79 nm/year, 95% CI 0.64 to 2.95), and BMO depth relative to BM increased in all groups except the suspects (control: -29.8 nm/year (95% CI -41.1 to -18.6), stable glaucoma: -21.5 nm/year (95% CI -34.9 to -8.0), progressing glaucoma: -36.3 nm/year (95% CI -60.4 to -12.3)). Axial length was not a significant factor in the rates of changes.

Conclusions : Bruch's membrane opening increased in axial bowing in progressing glaucoma eyes, and its axial position relative to Bruch's membrane became more posterior in both control and glaucoma eyes.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

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