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Mahadev Bhalla, Morgan Heisler, Sherry X. Han, Marinko V Sarunic, Mirza Faisal Beg, Paul Mackenzie, Sieun Lee; Longitudinal Analysis of the Bruch’s Membrane Opening Morphometrics in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5519.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate longitudinal changes in morphological characteristics of Bruch’s membrane opening (BMO) in control and glaucomatous subjects.
53 myopic eyes (17 control, 6 suspect, 10 progressing glaucoma, and 20 stable glaucoma) were followed for an average of 4.2 ± 1.4 years and imaged at the baseline and two follow-up appointments using a 1060nm swept-source optical coherence tomography system. Bruch’s membrane and Bruch's membrane opening (BMO) were segmented, and four morphometric BMO parameters (area, eccentricity, planarity, depth) were measured.
There was no significant changes in BMO area or eccentricity for all groups. BMO bowing, measured by BMO planarity, was shown to increase in the progressing glaucoma group (1.79 nm/year, 95% CI 0.64 to 2.95), and BMO depth relative to BM increased in all groups except the suspects (control: -29.8 nm/year (95% CI -41.1 to -18.6), stable glaucoma: -21.5 nm/year (95% CI -34.9 to -8.0), progressing glaucoma: -36.3 nm/year (95% CI -60.4 to -12.3)). Axial length was not a significant factor in the rates of changes.
Bruch's membrane opening increased in axial bowing in progressing glaucoma eyes, and its axial position relative to Bruch's membrane became more posterior in both control and glaucoma eyes.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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