July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma
Author Affiliations & Notes
  • Tadamichi Akagi
    Department of Ophthalmology and Visual Sciences, Kyoto Univ Graduate Sch of Med, Kyoto, Kyoto, Japan
  • Akihito Uji
    Department of Ophthalmology and Visual Sciences, Kyoto Univ Graduate Sch of Med, Kyoto, Kyoto, Japan
  • Yoko Okamoto
    Department of Ophthalmology and Visual Sciences, Kyoto Univ Graduate Sch of Med, Kyoto, Kyoto, Japan
  • Kenji Suda
    Department of Ophthalmology and Visual Sciences, Kyoto Univ Graduate Sch of Med, Kyoto, Kyoto, Japan
  • Takanori Kameda
    Department of Ophthalmology and Visual Sciences, Kyoto Univ Graduate Sch of Med, Kyoto, Kyoto, Japan
  • Hideo Nakanishi
    Department of Ophthalmology and Visual Sciences, Kyoto Univ Graduate Sch of Med, Kyoto, Kyoto, Japan
  • Hanako Ohashi Ikeda
    Department of Ophthalmology and Visual Sciences, Kyoto Univ Graduate Sch of Med, Kyoto, Kyoto, Japan
  • Masahiro Miyake
    Department of Ophthalmology and Visual Sciences, Kyoto Univ Graduate Sch of Med, Kyoto, Kyoto, Japan
  • Eri Nakano
    Department of Ophthalmology and Visual Sciences, Kyoto Univ Graduate Sch of Med, Kyoto, Kyoto, Japan
  • Naohiro Motozawa
    Department of Ophthalmology and Visual Sciences, Kyoto Univ Graduate Sch of Med, Kyoto, Kyoto, Japan
  • Akitaka Tsujikawa
    Department of Ophthalmology and Visual Sciences, Kyoto Univ Graduate Sch of Med, Kyoto, Kyoto, Japan
  • Footnotes
    Commercial Relationships   Tadamichi Akagi, Alcon (R), Bayer (R), Canon (R), Kowa (R), Pfizer (R), Santen (R), Senju (R); Akihito Uji, Alcon (R), Canon (R), Santen (R), Senju (R); Yoko Okamoto, None; Kenji Suda, Alcon (F), Kowa (R), Otsuka (R), Santen (R), Senju (R); Takanori Kameda, Alcon (R), Kowa (R), Pfizer (R), Santen (R), Senju (R), Tomey (F), Tomey (R); Hideo Nakanishi, Alcon (R), HOYA (R), Novartis (F), Pfizer (R), Santen (R), Tomey (F), Tomey (R); Hanako Ikeda, Alcon (F), Alcon (R), Kyoto Drug Descovery & Development (F), Novartis (F), Santen (R), Senju (R), Wakamoto (R); Masahiro Miyake, Alcon (R), HOYA (R), Japan Medical Instruments Association (R), Kowa (R), Santen (R); Eri Nakano, None; Naohiro Motozawa, None; Akitaka Tsujikawa, Alcon (F), AMO Japan (F), Atsuzawa (F), Bayer (F), Bayer (R), Canon (F), Daiichi Sankyo (R), HOYA (F), Janssen Pharma (R), Japan Medical Instruments Association (F), JFC (F), Johnson & Johnson (R), Kowa (F), Kyoto Drug Discovery & Development (R), Novartis (F), Novartis (R), Pfizer (F), Pfizer (R), Santen (F), Santen (R), Senju (F), Senju (R), Tomey (F), Wakamoto (F), Wakamoto (R)
  • Footnotes
    Support  Japan Society for the Promotion of Science KAKENHI Grant Number 16K11267
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5520. doi:https://doi.org/
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    • Get Citation

      Tadamichi Akagi, Akihito Uji, Yoko Okamoto, Kenji Suda, Takanori Kameda, Hideo Nakanishi, Hanako Ohashi Ikeda, Masahiro Miyake, Eri Nakano, Naohiro Motozawa, Akitaka Tsujikawa; Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5520. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate conjunctival and intrascleral vasculature in glaucoma eyes using anterior segment (AS)-optical coherence tomography angiography (OCTA) and assess the factors contributing to the vessel density in AS-OCTA images.

Methods : This prospective, observational, cross-sectional study included 34 patients with primary open-angle glaucoma and 20 healthy subjects. A swept-source OCT system was used to obtain AS-OCTA images of the corneal limbus at the nasal and temporal quadrants. Vessel densities were measured in the superficial (from the conjunctival epithelium to a depth of 200 μm) and deep (from a depth of 200 μm to 1000 μm) layers. The vessel density was compared between healthy and glaucoma eyes, and the associations of the vessel density with possible confounding factors were analyzed using univariable and multivariable analyses.

Results : The vessel density was not significantly different between healthy eyes and eyes with glaucoma. Superficial vessel density was significantly associated with glaucoma medications, especially the use of prostaglandin analog (P = .001 to .002), and the female gender (P = .003 to .047). Deep vessel density was significantly smaller with age (P = .029) in healthy eyes and larger with IOP (P = .020 to .045) in treated eyes with glaucoma.

Conclusions : AS-OCTA images might be useful for objective assessments for conjunctival hyperemia and might be helpful for understanding of the association between intrascleral vasculature and glaucoma.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Circumferential panoramic images of the vasculature acquired using OCTA in an eye with glaucoma.

Circumferential panoramic images of the vasculature acquired using OCTA in an eye with glaucoma.

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