July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
The application of Terahertz scanning system on corneas
Author Affiliations & Notes
  • Yu-Chi Liu
    Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS Medical School, Singapore, Singapore
  • Lin Ke
    Institute of Materials Research & Engineering, The Agency for Science, Technology and Research, Singapore, Singapore
  • Nan Zhang
    Institute of Materials Research & Engineering, The Agency for Science, Technology and Research, Singapore, Singapore
  • Ericia Teo
    Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore
  • Jodhbir Mehta
    Singapore National Eye Center, Singapore
  • Footnotes
    Commercial Relationships   Yu-Chi Liu, None; Lin Ke, None; Nan Zhang, None; Ericia Teo, None; Jodhbir Mehta, None
  • Footnotes
    Support  Singapore NMRC TA Grant R1482/65/2017
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6090. doi:
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    • Get Citation

      Yu-Chi Liu, Lin Ke, Nan Zhang, Ericia Teo, Jodhbir Mehta; The application of Terahertz scanning system on corneas. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6090.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the feasibility of using the Terahertz (THz) scanning system as a quantitative tool to evaluate corneal edema, and to evaluate the correlation between the signal intensity generated by the THz scanning and the central corneal thickness (CCT) measured by anterior segment optical coherence tomography (ASOCT).

Methods : Twenty human cadaveric corneas with different extents of corneal edema resulting from different preservation time were used. All the corneas were scanned weekly for longitudinal 3 weeks, with the TPS Spectra 3000 Teraview Terahertz scanning system and ASOCT (RTVue). The area under the curve (AUC) of the THz peak intensity from the spectral domain was calculated, and was correlated with the CCT measurements.

Results : At baseline (upon arrival), the THz scanning system had the capability to differentiate different extents of corneal edema resulting from different preservation time (Figure 1). The signal intensity increased with time as the cornea became more edematous (Figure 2). In the weekly continuous scans of these 20 corneas, a total of 400 THz scanning was obtained, and the AUC of signal intensity ranged from 6830±1289 to 13544±2593 atomic units/THz. The CCT ranged from 585±24to 1272±48μm. The AUC was positively and strongly correlated with the CCT (r = 0.77, P = 0.011) when the CCT < 800 μm. The correlation was slightly lower when the CCT > 800 μm but was still significant (r= 0.56; P= 0.014).

Conclusions : The Terahertz scanning has the potential to be used as a novel tool to quantitatively evaluate corneal edema. It may be helpful in monitoring the disease progression in patients with corneal edema.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

THz scanning system had the capability to differentiate different extents of corneal edema resulting from different preservation time. The more edematous cornea, the higher signal intensity.

THz scanning system had the capability to differentiate different extents of corneal edema resulting from different preservation time. The more edematous cornea, the higher signal intensity.

 

Representative scan showing the changes in the THz signal intensity in a human cornea for consecutive 3 weeks. A more edematous cornea (3rdweek > 2ndweek > 1stweek > baseline) had a higher signal amplitude.

Representative scan showing the changes in the THz signal intensity in a human cornea for consecutive 3 weeks. A more edematous cornea (3rdweek > 2ndweek > 1stweek > baseline) had a higher signal amplitude.

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