July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Dynamic Imaging of Ciliary Muscle and Pupil Changes During Accommodation
Author Affiliations & Notes
  • Yu-Cherng Chang
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Florence Cabot
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami, Florida, United States
    Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Marco Ruggeri
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami, Florida, United States
  • Arthur Ho
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami, Florida, United States
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
  • Sonia H Yoo
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami, Florida, United States
    Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Jean-Marie Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami, Florida, United States
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Footnotes
    Commercial Relationships   Yu-Cherng Chang, None; Florence Cabot, None; Marco Ruggeri, 8,425,037 (P); Arthur Ho, None; Sonia Yoo, None; Jean-Marie Parel, 8,425,037 (P); Fabrice Manns, 8,425,037 (P)
  • Footnotes
    Support  National Eye Institute Grants 1F30EY027162, 2R01EY14225, P30EY14801 (Center Grant); Florida Lions Eye Bank and the Beauty of Sight Foundation; Drs KR Olsen and ME Hildebrandt; Drs R Urs and A Furtado; the Henri and Flore Lesieur Foundation (JMP); an unrestricted grant from Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1400. doi:https://doi.org/
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      Yu-Cherng Chang, Florence Cabot, Marco Ruggeri, Arthur Ho, Sonia H Yoo, Jean-Marie Parel, Fabrice Manns; Dynamic Imaging of Ciliary Muscle and Pupil Changes During Accommodation. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1400. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Ciliary muscle and pupil contraction are both parasympathetic responses with a common neural origin, suggesting pupil behavior may be predictive of the level of muscle activity during processes where both are activated, namely accommodation. To explore the relationship between muscle and pupil changes during accommodation, we performed dynamic imaging of the accommodative responses of the muscle and pupil with Optical Coherence Tomography (OCT).

Methods : Left eyes from 4 subjects (22, 34, 39, and 45 y/o; -2.75, -1.44, -3.31, -9.19 SEQ, respectively) were imaged using a custom-built accommodation OCT system (Ruggeri et al, Biomed Opt Exp; 2012), capturing both ciliary muscle and anterior segment response to 2D accommodative step stimuli. Cross-sectional images were acquired at 13 frames/s with 897 A-lines/frame for the ciliary muscle and 400 A-lines/frame for the anterior segment. Stimulus presentation occurred 1.54 s from the start of the trial.
Ciliary muscle maximum thickness (CMT) and pupil diameter (PD) were determined for each image. CMT was derived from manual segmentation of ciliary muscle images as the thickness measured at the muscle apex. PD was derived from automatic segmentation of anterior segment images. Changes in CMT and PD were determined as the difference between the average CMT and PD for the last and first 20 images (a sign change was applied to PD for ease of viewing).

Results : Quantification of accommodative ciliary muscle and pupil changes are detailed in Table 1. Plots of the responses of the ciliary muscle and pupil change over time during an imaging session are shown in Figure 1. Plots suggest synchronized movement of the muscle and pupil, confirmed through high cross correlation coefficients between the muscle and pupil responses.

Conclusions : Synchronization of CMT and PD during accommodation suggests pupil changes may be indicative of muscle activity and, given the role of the muscle in starting accommodation, may be further indicative of accommodative effort.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Table 1: Accommodative ciliary muscle and pupil changes for all subjects in response to a 2D step stimulus.

Table 1: Accommodative ciliary muscle and pupil changes for all subjects in response to a 2D step stimulus.

 

Figure 1: Plots of CM change and PD change in a 22 (A), 34 (B), 39 (C), 45 (D) y/o responding to a 2D accommodative step stimulus. Red dotted line represents onset of stimulus change. In these plots, the sign of PD change was reversed.

Figure 1: Plots of CM change and PD change in a 22 (A), 34 (B), 39 (C), 45 (D) y/o responding to a 2D accommodative step stimulus. Red dotted line represents onset of stimulus change. In these plots, the sign of PD change was reversed.

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