July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Assessment of retinal curvature, choroidal thickness, and peripheral refraction over a 90-degree field of view in emmetropic and myopic human eyes.
Author Affiliations & Notes
  • Jochen Straub
    Carl Zeiss Meditec, Dublin, California, United States
  • Conor Leahy
    Carl Zeiss Meditec, Dublin, California, United States
  • Katharina G Foote
    Carl Zeiss Meditec, Dublin, California, United States
    School of Optometry and Vision Science, University of California, Berkeley, California, United States
  • Homayoun Bagherinia
    Carl Zeiss Meditec, Dublin, California, United States
  • Simon Bello
    Carl Zeiss Meditec, Dublin, California, United States
  • Footnotes
    Commercial Relationships   Jochen Straub, Carl Zeiss Meditec, Inc. (E); Conor Leahy, Carl Zeiss Meditec, Inc. (E); Katharina Foote, Carl Zeiss Meditec, Inc. (C); Homayoun Bagherinia, Carl Zeiss Meditec, Inc. (E); Simon Bello, Carl Zeiss Meditec, Inc. (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1599. doi:
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      Jochen Straub, Conor Leahy, Katharina G Foote, Homayoun Bagherinia, Simon Bello; Assessment of retinal curvature, choroidal thickness, and peripheral refraction over a 90-degree field of view in emmetropic and myopic human eyes.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1599.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The purpose of our pilot study is to evaluate novel tools for myopia research. We acquire data on human eyes using new tools to estimate retinal curvature, and to measure choroidal thickness and peripheral refraction.

Methods : Retinal curvature and choroidal thickness were assessed using a prototype 200 kHz swept-source optical coherence tomography system (OCT) with a 90-degree field of view. Retinal curvature was estimated using the method described by Steidle in Biophotonics: Photonic Solutions for Better Health Care VI (2018). Peripheral refraction was measured using a CLARUSTM 500 fundus imager (ZEISS, Dublin, CA) using the method described by Everett (ARVO 2018). A total of 42 eyes of 21 subjects were enrolled in the study. OCT scans were acquired in 26 eyes of 13 subjects. Peripheral refraction was measured in 42 eyes of 21 subjects.

Results : Figure 1 shows retinal OCT scans with choroidal segmentation. Figure 2 shows axial eye length vs. refractive error, relative peripheral refraction, central choroidal thickness and retinal curvature. Refractive errors ranged from -14.5 to +4.0 diopters, axial length from 21.92 to 29.81mm, central choroidal thickness from 93 to 440 microns, peripheral refraction from -2.15 to +9.0 diopters and retinal radius of curvature from 10.8 to 16.0mm. We found a strong correlation between axial eye length and refractive error (OD: r=-0.86, 95% CI -0.94 to -0.70, p<0.01; OS: r=-0.83, 95% CI -0.94 to -0.69, p<0.01) and a moderate correlation between axial eye length and peripheral refraction (OD: r=0.80, 95% CI 0.56 to 0.92, p<0.01; OS: r=0.60, 95% CI 0.23 to 0.82, p<0.01). We found a weak correlation between axial eye length and central choroidal thickness or retinal curvature.

Conclusions : Our pilot study has shown that we can measure peripheral refraction, estimate retinal curvature, and measure choroidal thickness of the human eye up to a field of view of 90 degrees using our novel tools. These tools can be useful for research in the anatomy of the human eye and as diagnostic tools in myopia control.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Estimation of retinal curvature and choroidal thickness. Left: Widefield OCT scan of a mildly myopic eye. Right: Scan showing the retinal shape and an overlay of the segmentation layers.

Estimation of retinal curvature and choroidal thickness. Left: Widefield OCT scan of a mildly myopic eye. Right: Scan showing the retinal shape and an overlay of the segmentation layers.

 

Axial eye length vs. refractive error, peripheral refraction, central choroidal thickness and retinal radius of curvature.

Axial eye length vs. refractive error, peripheral refraction, central choroidal thickness and retinal radius of curvature.

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