Abstract
Purpose :
Steroid-induced glaucoma is famous for side effect of steroid use, but epidemiology of steroid-induced glaucoma in Japan has not been illustrated well. Our aim in this study is to reveal the clinical characteristics of eyes with steroid use in Japanese glaucoma clinics.
Methods :
Patients with steroid use who had visited the glaucoma clinic in Kyoto University Hospital between August 2011 and October 2017 were included. We investigated their age at first visit and mean deviation (MD) of visual field tests (Humphrey field analyzer (HFA) SITA Standard 24-2) at first and final visits, and highest intraocular pressure (IOP) in the clinical record and compared their average between the reasons for steroid use. The correlation between two parameters among age, MD and highest IOP was evaluated by Pearson’s correlation coefficient.
Results :
A total of 382 eyes of 196 patients (mean age, 52.4 ± 18.3 years) were included. The average of MD was -6.6 ± 7.1 dB at first visit and -7.6 ± 8.0 dB at final visit (mean observation duration, 82.3 ± 48.0 months). The average of highest IOP was 26.9 ± 10.9 mmHg. The most frequent disease as the reason of steroid use was atopic dermatitis (58 eyes), followed by autoimmune diseases (systemic lupus erythematosus 44 eyes; interstitial pneumonia 26 eyes; rheumatoid arthritis 26 eyes). The patients with atopic dermatitis was significantly younger (38.0 ± 11.2 years old, p < 0.001) and had lower MD (-9.3 ± 9.1 dB at first visit, p = 0.01; -10.6 ± 9.2 dB at final visit, p = 0.004) than those with other diseases. Highest IOP in the clinical course was correlated significantly with MD at final visit (r = -0.41, p < 0.001).
Conclusions :
Patients with atopic dermatitis have high risk of visual field loss at an early age. Regular measurement of intraocular pressure is essential for preventing glaucoma progression.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.