July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Age-related increase in anterior optic nerve head compression in response to IOP elevation
Author Affiliations & Notes
  • Yanhui Ma
    Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States
  • Elias Pavlatos
    Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States
  • Xueliang Pan
    Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, United States
  • Sunny Kwok
    Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States
  • Keyton Clayson
    Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States
    Biophysics Interdisciplinary Group, The Ohio State University, Columbus, Ohio, United States
  • Jun Liu
    Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States
    Department of Ophthalmology and Visual Science, The Ohio State University, Columbus, Ohio, United States
  • Footnotes
    Commercial Relationships   Yanhui Ma, None; Elias Pavlatos, None; Xueliang Pan, None; Sunny Kwok, None; Keyton Clayson, None; Jun Liu, None
  • Footnotes
    Support  RO1EY020929 and RO1EY025358
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2246. doi:
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    • Get Citation

      Yanhui Ma, Elias Pavlatos, Xueliang Pan, Sunny Kwok, Keyton Clayson, Jun Liu; Age-related increase in anterior optic nerve head compression in response to IOP elevation. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2246.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To quantify the regional mechanical responses of human optic nerve head (ONH) and peripapillary tissue (PPT) and to investigate age-associated changes in the mechanical responses.

Methods : Inflation tests were performed in 15 human donor eyes (age: 20-78 years old) with intraocular pressure (IOP) increase from 15 to 17, 19, 22, 25 and 30 mmHg and a 10 min equilibration at each step. A 3D volume of posterior eye centered at the ONH (10 mm × 10 mm) was scanned at each pressure step using a 50MHz ultrasound probe (MS700, Vevo2100, VisualSonics). A correlation-based 3D speckle tracking algorithm (Cruz Perez et al, ABME, 2015) was used to compute tissue displacements, and the Green strain tensor in the Cartesian coordinate was calculated using least squares estimation. Through-thickness (TT), circumferential, meridional and shear strains in spherical coordinates were obtained by coordinate transformation. Average regional strains at 30 mmHg were obtained and their association with age was evaluated using Pearson correlation.

Results : Compressive TT strains were observed both in the ONH (-2.18%±0.53%) and the PPT (-3.15%±0.68%) with a much larger magnitude compared to circumferential strains (0.05%±0.14% in ONH and 0.13%±0.07% in PPT) and meridional strains (0.30%±0.18% in ONH and 0.16%±0.13% in PPT). Through-thickness compression was concentrated in the anterior region (Fig.1). The magnitude of compressive TT strain in the anterior ONH was positively correlated with age (R=0.56, p=0.028), while ONH in-plane shear strain appeared to be negatively correlated with age (R= -0.50, p=0.055, Fig.2).

Conclusions : Previous studies have shown an age-related stiffening in the collagenous tissue of the posterior eye. Our study showed an age-related decrease in ONH shear (i.e., stiffening); however, through-thickness compression increased with age in the anterior ONH, which is largely composed of glial cells and neural tissue. This result may provide new insights into the age-associated biomechanical susceptibility to glaucoma, particularly in the anterior ONH where glaucoma damages initiate.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Fig.1 Ultrasound images (top) and TT strain maps (bottom) for 2 human donor eyes: 24 yo (left) and 78 yo (right). Cross-section is in the inferior-superior direction at the central plane of scanned 3D volume

Fig.1 Ultrasound images (top) and TT strain maps (bottom) for 2 human donor eyes: 24 yo (left) and 78 yo (right). Cross-section is in the inferior-superior direction at the central plane of scanned 3D volume

 

Fig.2 A. Compressive strain increased with age in anterior ONH; B. in-plane shear decreased with age in ONH

Fig.2 A. Compressive strain increased with age in anterior ONH; B. in-plane shear decreased with age in ONH

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