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Sarakshi Mahajan, Muhammad Sohail Halim, Muhammad Hassan, Maria Soledad Ormaechea, Günay Uludağ, Anh Ngoc Tram Tran, Jeong Hun Bae, Rubbia Afridi, Samendra Karkhur, Murat Hasanreisoglu, Aarin Pham, Khalid Yusuf Yaseen Al-Kirwi, Diana V Do, Quan Dong Nguyen, Yasir Jamal Sepah; Assessing Scleral Area Vessel Density in Subjects with Anterior Scleritis using Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2019;60(9):3084. doi: https://doi.org/.
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To measure and assess the scleral area vessel density (SAVD) in subjects with active anterior scleritis and compare to subjects without scleral inflammation.
Subjects with a clinical diagnosis of anterior scleritis and healthy subjects from a uveitis clinic at a tertiary care hospital were enrolled in the study. All the subjects initially underwent 9 cardinal gaze slit-lamp photography. A customized protocol published previously in ARVO abstract 2018 was utilized to obtain optical coherence tomography angiography (OCTA) of the scleral vessels in the temporal portion of the sclera using Optovue Angiovue (Optovue, Inc., California, USA). SAVD was measured using ReVue software ( Version 2017.1.0.151). Grading of scleritis in the temporal scleral area and the area with highest degree of scleral inflammation were graded by 2 independent graders using a standardized scleritis grading scale (Sen 2011). Adjudication was performed in cases of differences between the primary graders. The correlation was made between: 1) highest grade of scleritis and 2) grade of scleritis in the temporal scleral area with the SAVD using linear regression analysis.
Sixty-one eyes (29: active scleritis and 32: no scleral inflammation) were included in the study. The mean age of study subjects was 41 years. 69% of the subjects were female. Mean SAVD in eyes with active scleritis was 56.89±1.20 %. Mean SAVD in eyes without scleral inflammation was 53.98±0.79 %. Mean difference in the SAVD between eyes with active scleritis and eyes without scleral inflammation was statistically significant (p=0.042). Regression analysis showed a statistically significant correlation between the highest grade of scleritis and the SAVD (r= 0.07,p=0.015) (figure 1). Similarly, there was a significant correlation between the grade of scleritis in the temporal scleral area and the SAVD (r= 0.15, p=0.001) (figure 2).
The SAVD in eyes with active scleritis is significantly higher than in eyes without scleral inflammation. SAVD may be employed in objective assessment of scleral inflammation.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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