July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Relationship between CC Impairment and GA Growth: An Optical Coherence Tomography Angiography Study
Author Affiliations & Notes
  • Eric Moult
    MIT, Cambridge, Massachusetts, United States
  • A. Yasin Alibhai
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts, United States
  • Byungkun Lee
    MIT, Cambridge, Massachusetts, United States
  • Stefan B Ploner
    Computer Science, Friedrich-Alexander University, Erlangen, Bavaria, Germany
  • Andreas K Maier
    Computer Science, Friedrich-Alexander University, Erlangen, Bavaria, Germany
  • Jay S Duker
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts, United States
  • Nadia K Waheed
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts, United States
  • James G Fujimoto
    MIT, Cambridge, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Eric Moult, IP related to VISTA (P); A. Yasin Alibhai, None; Byungkun Lee, None; Stefan Ploner, IP related to VISTA (P); Andreas Maier, None; Jay Duker, Carl Zeiss Meditec (F), Carl Zeiss Meditec (C), Optovue (F), Optovue (C), Topcon (F), Topcon (C); Nadia Waheed, Carl Zeiss Meditec (F), Heidelberg (F), MVRF (F), Nidek (F), Optovue (C), Topcon (F); James Fujimoto, AFOSR (F), Carl Zeiss Meditec (P), IP related to VISTA (P), NIH (F), Optovue (P), Optovue (C), Optovue (I), Topcon (F)
  • Footnotes
    Support  NIH 5-R01-EY011289-31, AFOSR FA9550-15-1-0473, Macula Vision Research Foundation (MVRF), Champalimaud Vision Award, Beckman-Argyros Award in Vision Research, Massachusetts Lions Clubs.
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4220. doi:
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      Eric Moult, A. Yasin Alibhai, Byungkun Lee, Stefan B Ploner, Andreas K Maier, Jay S Duker, Nadia K Waheed, James G Fujimoto; Relationship between CC Impairment and GA Growth: An Optical Coherence Tomography Angiography Study. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4220.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To use optical coherence tomography angiography (OCTA) to answer three questions regarding the relationship between choriocapillaris (CC) impairment and the rate of geographic atrophy (GA) growth: (1) Is global CC impairment correlated with global GA growth rate? (2) Is CC impairment immediately adjacent to the GA margin more correlated with global GA growth rate than is CC impairment farther from the GA margin? (3) Does GA preferentially grow into regions of CC impairment?

Methods : Eight eyes from 6 patients with GA secondary to age-related macular degeneration (AMD) were imaged with a prototype 400kHz, 1050nm swept-source OCTA system at two visits (mean intervisit time: 8 ± 2.1 months). Of these 8 eyes, 1 eye was excluded from the statistical analysis due to the presence of peripapillary atrophy. For each eye, baseline CC impairment—assessed using flow deficit percentage—was computed using global, zonal, and local perspectives, and then correlated with global and local GA growth rates.

Results : Global baseline CC impairment was found to be correlated with global GA growth rate (Pearson’s r = 0.83, p = 0.02). Zonal analysis did not support the hypothesis that baseline CC impairment immediately adjacent to the GA margin was more correlated with GA growth rate than was baseline CC impairment farther from the margin. Finally, local analysis did not support the hypothesis that GA lesions preferentially grow into regions of CC impairment (mean Pearson’s r = -0.06).

Conclusions : Global CC impairment, excluding the region of atrophy, may be a useful predictor of GA growth rates. CC impairment in zones immediately adjacent to the GA margin were not more correlated with GA growth rates than were CC impairment in zones farther from the margin. Furthermore, in general, GA lesions were not found to grow into regions of CC impairment, suggesting that local CC impairment is, in general, not directly causal in local GA growth.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Measures of CC impairment (top) and GA growth (bottom) in global, zonal, and local perspectives.

Measures of CC impairment (top) and GA growth (bottom) in global, zonal, and local perspectives.

 

Top: Description of cases. Bottom: global and zonal correlations between CC impairment and GA growth; due to space limitations, local correlation plots are not shown. In (A): diamonds = unifocal lesions; circles = multifocal lesions; C1-C8 indicate cases 1-8; C2 was excluded (peripapillary atrophy). In (A) and (B): filled markers = 1.5ms interscan time; open markers = 3.0ms.

Top: Description of cases. Bottom: global and zonal correlations between CC impairment and GA growth; due to space limitations, local correlation plots are not shown. In (A): diamonds = unifocal lesions; circles = multifocal lesions; C1-C8 indicate cases 1-8; C2 was excluded (peripapillary atrophy). In (A) and (B): filled markers = 1.5ms interscan time; open markers = 3.0ms.

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