July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Correlation of Clinical Aqueous Flare Grade to Semi-automated Flare Assessment using Laser Flare Meter
Author Affiliations & Notes
  • Anh Ngoc Tram Tran
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Muhammad Sohail Halim
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Muhammad Hassan
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Murat Hasanreisoglu
    Ophthalmology, Gazi University, School of Medicine, Ankara, Turkey
  • Rubbia Afridi
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Maria Soledad Ormaechea
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
    Ophthalmology, Hospital Universitario Austral, Pilar, Buenos Aires, Argentina
  • Günay Uludağ
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Nam V Nguyen
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Sarakshi Mahajan
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Jeong Hun Bae
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
    Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
  • Khalid Yusuf Yaseen Al-Kirwi
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Diana V Do
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Mohamed A Ibrahim
    Ocular Imaging Research and Reading Center, Menlo Park, California, United States
  • Yasir Jamal Sepah
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Quan Dong Nguyen
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Footnotes
    Commercial Relationships   Anh Tran, None; Muhammad Sohail Halim, None; Muhammad Hassan, None; Murat Hasanreisoglu, None; Rubbia Afridi, None; Maria Ormaechea, None; Günay Uludağ, None; Nam Nguyen, None; Sarakshi Mahajan, None; Jeong Hun Bae, None; Khalid Al-Kirwi, None; Diana Do, None; Mohamed Ibrahim, Ocular Imaging Research and Reading Center (E); Yasir Jamal Sepah, None; Quan Nguyen, None
  • Footnotes
    Support  NEI P30-EY026877, and Research to Prevent Blindness, Inc
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6481. doi:https://doi.org/
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      Anh Ngoc Tram Tran, Muhammad Sohail Halim, Muhammad Hassan, Murat Hasanreisoglu, Rubbia Afridi, Maria Soledad Ormaechea, Günay Uludağ, Nam V Nguyen, Sarakshi Mahajan, Jeong Hun Bae, Khalid Yusuf Yaseen Al-Kirwi, Diana V Do, Mohamed A Ibrahim, Yasir Jamal Sepah, Quan Dong Nguyen; Correlation of Clinical Aqueous Flare Grade to Semi-automated Flare Assessment using Laser Flare Meter. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6481. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To correlate aqueous flare values obtained using laser flare meter with clinical aqueous flare grading using standardization of uveitis nomenclature (SUN) grading scale.

Methods : Patients with clinical diagnosis of anterior, intermediate, posterior, and pan-uveitis were enrolled from a uveitis clinic at a tertiary hospital. All patients initially underwent a dilated ophthalmological examination where clinician’s assessment of aqueous flare using SUN grading scale was recorded. Subsequently, a masked operator performed aqueous flare measurements (≥5) on patients using laser flare meter (Kowa FM-700). Mean aqueous flare measurement values (±SD) as assessed by laser flare meter corresponding to the clinician’s assessment of aqueous flare were correlated. Additionally, we modified the aqueous flare grading by adding additional grading steps (0.5+ and 1.5+) to the current SUN aqueous flare grading scale and correlated with the corresponding laser flare meter measurements.

Results : Two hundred and twenty-nine (229) aqueous flare measurements (108 subjects) were analyzed for this prospective study. 45 females (58.33%); mean age 50.30 ± 15.32 years. Of these measurements, 89 were clinically assessed as no flare, 112 as 1+ flare, and 28 as 2+ flare (SUN Grade). The mean (±SE) aqueous flare measurement values for the clinical grades of the aqueous flare were 5.00 (±1.38), 11.42 (±7.50), and 30.54 (±23.22) photon counts/millisecond for no flare, 1+ flare, and 2+ flare, respectively (Figure 1). The differences among the mean aqueous flare values for clinically assigned SUN aqueous flare grades were deemed statistically significant (p<0.0001). The mean values of the aqueous flare measurements for the modified grading scale are shown in Figure 2. There were significant differences between the mean aqueous flare values when comparing no flare to 0.5+ flare and 1+ flare to 1.5+ flare (p<0.0001).

Conclusions : Laser flare meter provides reliable quantitative assessments of aqueous flare that correlate with the clinician’s assessment. Our results also suggest that adding grading steps of 0.5+ and 1.5+ to the current SUN grading may allow finer differentiation of aqueous flare.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Figure 1. Mean aqueous flare measurement values using SUN grading scale and clinician’s assessment of aqueous flare

Figure 1. Mean aqueous flare measurement values using SUN grading scale and clinician’s assessment of aqueous flare

 

Figure 2. Mean aqueous flare measurement values using modified grading scale and clinician’s assessment of aqueous flare

Figure 2. Mean aqueous flare measurement values using modified grading scale and clinician’s assessment of aqueous flare

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