July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Ultrahigh-Resolution SD-OCT of the Human Retina with Extended Imaging Range Using Reference Arm Length Modulation
Author Affiliations & Notes
  • ByungKun Lee
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Siyu Chen
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Eric Moult
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • A. Yasin Alibhai
    Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts, United States
  • Oscar Carrasco-Zevallos
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Lennart Husvogt
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
    Pattern Recognition Lab, University of Erlangen-Nuremberg, Erlangen, Bavaria, Germany
  • Nihaal Mehta
    Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts, United States
  • Nadia K Waheed
    Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts, United States
  • Jay S Duker
    Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts, United States
  • James G Fujimoto
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Footnotes
    Commercial Relationships   ByungKun Lee, None; Siyu Chen, None; Eric Moult, None; A. Yasin Alibhai, None; Oscar Carrasco-Zevallos, None; Lennart Husvogt, None; Nihaal Mehta, None; Nadia Waheed, Carl Zeiss Meditec (F), Genentech (R), Genetech (C), Janssen (R), Macular Research Foundation (F), Nidek (R), Ocudyne (R), Optovue (R), Optovue (F), Regeneron (C); Jay Duker, Allergan (C), Aura Biosciences (C), Carl Zeiss Meditec (F), Carl Zeiss Meditec (C), Eleven Biotherapeutics (E), Hemera Boisciences (I), Lumenis (C), Ocudtne (C), Omeros (C), Opthotech (I), Optovue (F), Optovue (C), pSivida Corporation (E), Santen (C), Thrombogenics (C); James Fujimoto, Optovue (I), Optovue (P)
  • Footnotes
    Support  NIH Grant R01-EY011289-30
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1593. doi:
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      ByungKun Lee, Siyu Chen, Eric Moult, A. Yasin Alibhai, Oscar Carrasco-Zevallos, Lennart Husvogt, Nihaal Mehta, Nadia K Waheed, Jay S Duker, James G Fujimoto; Ultrahigh-Resolution SD-OCT of the Human Retina with Extended Imaging Range Using Reference Arm Length Modulation. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1593.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To develop high-speed, extended-range, ultrahigh-resolution spectral-domain optical coherence tomography (UHR SD-OCT) and demonstrate scan protocols for retinal imaging.

Methods : A high-performance 840-nm spectrometer based on a high-speed 2048-pixel camera with line rates up to 250 kHz was used to achieve 3.1-µm axial resolution and 1.3-mm 6-dB imaging range in tissue. Reference arm length modulation (ReALM) allowed the axial imaging window to follow the contour of the retina, in order to increase the effective imaging range. High-definition (HD) raster scans covering 9 mm×6 mm field of view (FOV) with 1800×241 A-scans were acquired in 3.8 seconds to visualize cross-sectional details of the outer retina. Software-motion-corrected volumes were generated from a pair of perpendicular raster scans, each of which covered 6 mm×6 mm or 9 mm×9 mm FOV with 500×500 A-scans acquired in 2.3 seconds. Linear signal display (no logarithmic compression) was selectively used for enhanced UHR visualization.

Results : UHR SD-OCT was evaluated at 128 kHz and 250 kHz A-scan rates with motion-corrected volumes and HD raster scans in healthy subjects and subjects with dry age-related macular degeneration (AMD). In healthy eyes, the rod interdigitation zones, retinal pigment epithelium (RPE), and Bruch’s membrane were clearly resolved. Eyes with dry AMD exhibited reduced sharpness and impairment of these structures.

Conclusions : The proposed UHR SD-OCT system achieves high-speeds and extended effective imaging ranges, thereby enabling wider FOV and practical volumetric scan protocols. These developments may facilitate clinical UHR studies of outer retinal markers of AMD progression.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Motion-corrected volume generated from a pair of 500×500 raster scans over 9 mm×9 mm macular area of an eye with dry AMD. (A1-A7, B1-B7) ReALM compensates for the retinal contour across different B-scans. (C1-C7) motion correction removes the axial displacement introduced either by patient motion or by ReALM. Scale bars: 1 mm.

Motion-corrected volume generated from a pair of 500×500 raster scans over 9 mm×9 mm macular area of an eye with dry AMD. (A1-A7, B1-B7) ReALM compensates for the retinal contour across different B-scans. (C1-C7) motion correction removes the axial displacement introduced either by patient motion or by ReALM. Scale bars: 1 mm.

 

B-scans at the position 2mm superior to the fovea, taken from 1800×241 HD raster scans covering 9 mm×6 mm macular area. Linear signal display of a 125-um outer retinal slab shows that the photoreceptor layers appear less sharp in dry AMD (A, C) compared to the age-matched controls (B, D). Scale bars: 500 μm.

B-scans at the position 2mm superior to the fovea, taken from 1800×241 HD raster scans covering 9 mm×6 mm macular area. Linear signal display of a 125-um outer retinal slab shows that the photoreceptor layers appear less sharp in dry AMD (A, C) compared to the age-matched controls (B, D). Scale bars: 500 μm.

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