July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
A web-based interface for ocular hemodynamics and biomechanics analysis via the Ocular Mathematical Virtual Simulator
Author Affiliations & Notes
  • Lorenzo Sala
    Université de Strasbourg, Strasbourg, France
  • Giovanna Guidoboni
    Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, United States
    Department of Mathematics, University of Missouri, Columbia, Missouri, United States
  • Christophe Prud'homme
    Université de Strasbourg, Strasbourg, France
  • Marcela Szopos
    Université Paris Descartes, Paris, France
  • Alice Chandra Verticchio Vercellin
    Ophthalmology, University of Pavia, Pavia, Italy
    IRCCS - Fondazione Bietti, Rome, Italy
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Lorenzo Sala, None; Giovanna Guidoboni, None; Christophe Prud'homme, None; Marcela Szopos, None; Alice Chandra Verticchio Vercellin, None; Brent Siesky, None; Alon Harris, AdOM (C), AdOM (I), CIPLA (C), Oxymap (I), Shire (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4277. doi:https://doi.org/
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    • Get Citation

      Lorenzo Sala, Giovanna Guidoboni, Christophe Prud'homme, Marcela Szopos, Alice Chandra Verticchio Vercellin, Brent A Siesky, Alon Harris; A web-based interface for ocular hemodynamics and biomechanics analysis via the Ocular Mathematical Virtual Simulator. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4277. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optic neuropathies such as glaucoma are often late-onset, progressive and incurable diseases.
Principally, these disorders are caused by pathogenic hemodynamics and biomechanics in the back of the eye.
Data on ocular posterior tissues are difficult to estimate non-invasively and their clinical interpretation remains challenging due to the interaction among multiple factors that are not easily isolated.
We have developed a user-friendly web interface that employs the Ocular Mathematical Virtual Simulator (OMVS) to perform real-time simulations estimating ocular hemodynamical and biomechanical conditions based on patient-specific input data.

Methods : The OMVS (Fig. 1a) combines 1) a three-dimensional (3d) porous-media model for lamina cribrosa (LC) perfusion with 2) a circuit-based model for blood flow in retrobulbar and ocular posterior segments and 3) a 3d elastic model to simulate the biomechanics of LC, retina, choroid, sclera, and cornea.
Systems 1), 2) and 3) are solved using advanced computational methods (Feel++,OpenModelica) within a web simulation interface (Fig. 1c) that provides two applications: i) the OMVS View App (Fig. 1d), allowing the user to explore the simulation results that are stored in a private database, and ii) the OMVS Compare App (Fig. 1b), supporting a comparative analysis of multiple assessments of different patients or of the same patient at different visits.

Results : A virtual patient database (Fig. 2a) made of synthetic data inspired by the clinical literature was generated to test the web interface, which is used as a virtual laboratory for hemodynamical and biomechanical analysis.
Fig. 2b suggests that virtual patients with high intraocular pressure (IOP) have a decrease (up to 66%) in central retinal vessels blood flow; however this reduction is less important in subjects suffering from high intracranial pressure (ICP) and/or high systolic/diastolic blood pressure (BP, Figs. 2c and 2d, up to 64% and 58%, respectively).

Conclusions : The OMVS web-interface provides an accessible environment where the user can isolate single risk factors and inspect their influence on the overall system.
The proposed interface may serve as a complementary method of data analysis and visualization for clinical and experimental research and a training application for educational purposes.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

OMVS web tool overview

OMVS web tool overview

 

OMVS database and simulation results varying IOP, ICP and BP

OMVS database and simulation results varying IOP, ICP and BP

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