July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Assessing Foveal Cone Mosaic in White Dot Syndromes
Author Affiliations & Notes
  • Muhammad Sohail Halim
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Maria Soledad Ormaechea
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
    Ophthalmology, Hospital Universitario Austral, Pilar, Buenos Aires, Argentina
  • Nripun Sredar
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Günay Uludağ
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Moataz M Razeen
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Anh Ngoc Tram Tran
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Sarakshi Mahajan
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Muhammad Hassan
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Rubbia Afridi
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Khalid Yusuf Yaseen Al-Kirwi
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Jeong Hun Bae
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Diana V Do
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Yasir Jamal Sepah
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Alfredo Dubra
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Quan Dong Nguyen
    Byers Eye Institute, Palo Alto, CA, Palo Alto, California, United States
  • Footnotes
    Commercial Relationships   Muhammad Sohail Halim, None; Maria Ormaechea, None; Nripun Sredar, None; Günay Uludağ, None; Moataz Razeen, None; Anh Tran, None; Sarakshi Mahajan, None; Muhammad Hassan, None; Rubbia Afridi, None; Khalid Al-Kirwi, None; Jeong Hun Bae, None; Diana Do, None; Yasir Jamal Sepah, None; Alfredo Dubra, None; Quan Nguyen, None
  • Footnotes
    Support  NEI P30-EY026877, and Research to Prevent Blindness, Inc.
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 4586. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Muhammad Sohail Halim, Maria Soledad Ormaechea, Nripun Sredar, Günay Uludağ, Moataz M Razeen, Anh Ngoc Tram Tran, Sarakshi Mahajan, Muhammad Hassan, Rubbia Afridi, Khalid Yusuf Yaseen Al-Kirwi, Jeong Hun Bae, Diana V Do, Yasir Jamal Sepah, Alfredo Dubra, Quan Dong Nguyen; Assessing Foveal Cone Mosaic in White Dot Syndromes. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4586. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To examine the cone-photoreceptor mosaic in patients with white dot syndromes using confocal adaptive optics scanning light ophthalmoscopy (AOSLO).

Methods : Five patients (8 eyes) with white dot syndromes (Table) were imaged using an AOSLO. One healthy female subject (2 eyes) was also included in the study for comparison. Image sequences (150 frames), of 1.0° and 1.5° field of view, spanning the depth of the retina were captured using 790 nm light (54 μW at the pupil). Fifty frames of each sequence were registered and averaged to improve the signal-to-noise ratio. A semi-automatic MATLAB algorithm was used to identify cone-centers in the region of interest (ROI). The number of cones per degree2 were calculated for each eye. Subsequently, the number of neighbors for each cone was measured using Voronoi tiling. Percentage of cones with abnormal number (<5 or >7) of neighboring cones were calculated.

Results : The mean age of patients was 41 years (range: 18 to 84 years). The age of the control subject was 31 years. Four (80%) of the patients were females. Number of cone photoreceptors per degree2 and the percentage of cones with abnormal number of neighboring cone photoreceptors were tabulated and shown in Table below. Subjects with white dot syndromes had lower cone density (13-70%) and more abnormal neighbors (40-190%) compared to normal eyes (Figure).

Conclusions : Adaptive optics enables detailed visualization of structural integrity of cone photoreceptors in the retina. Patients with birdshot chorioretinopathy and maculopathy demonstrated the least number of cones per degree2 compared to normal eyes.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Table: Comparison of Structural Differences in Cone Photoreceptors

Table: Comparison of Structural Differences in Cone Photoreceptors

 

Figure: Confocal Foveal Cone Mosaic and Density Measurements of Various White Dot Syndromes

Figure: Confocal Foveal Cone Mosaic and Density Measurements of Various White Dot Syndromes

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×