July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Optical Coherence Tomography (OCT) Optic Nerve Head (ONH) Neural Canal Direction, Obliqueness and Minimum Cross-sectional Area in Highly Myopic versus Age-Matched Healthy Eyes
Author Affiliations & Notes
  • Jin Wook Jeoung
    Devers Eye Institute Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon, United States
    Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Hongli Yang
    Devers Eye Institute Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon, United States
    Devers Eye Institute Discoveries in Sight Research Laboratories, Legacy Research Institute, Portland, Oregon, United States
  • Stuart Keith Gardiner
    Devers Eye Institute Discoveries in Sight Research Laboratories, Legacy Research Institute, Portland, Oregon, United States
  • Yaxing Wang
    Devers Eye Institute Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon, United States
    Ophthalmology, Beijing Tongren Hospital, Beijing, China
  • Seung Woo Hong
    Department of Ophthalmology, the Catholic University of Korea, Seoul, Korea (the Republic of)
  • Michael J A Girard
    Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore
  • Christy A Hardin
    Devers Eye Institute Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon, United States
    Devers Eye Institute Discoveries in Sight Research Laboratories, Legacy Research Institute, Portland, Oregon, United States
  • Ping Wei
    Devers Eye Institute Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon, United States
    Devers Eye Institute Discoveries in Sight Research Laboratories, Legacy Research Institute, Portland, Oregon, United States
  • Jayme Vianna
    Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Balwantray C Chauhan
    Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Claude F Burgoyne
    Devers Eye Institute Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon, United States
    Devers Eye Institute Discoveries in Sight Research Laboratories, Legacy Research Institute, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Jin Wook Jeoung, Allergan (C), PH Pharma (F), Santen (C); Hongli Yang, None; Stuart Gardiner, Heidelberg Engineering (C); Yaxing Wang, None; Seung Woo Hong, None; Michael Girard, Abyss Processing Pte Ltd. (S); Christy Hardin, None; Ping Wei, None; Jayme Vianna, None; Balwantray Chauhan, Allergan (C), CenterVue (F), Heidelberg Engineering (C), Heidelberg Engineering (F), Topcon (F); Claude Burgoyne, Heidelberg Engineering (C), Heidelberg Engineering (F), Heidelberg Engineering (S)
  • Footnotes
    Support  NIH R01 EY021281, Legacy Good Samaritan Devers Eye Institute Foundation Funds, Canadian National Institute for the Blind, Canadian Glaucoma Clinical Research Council; Heidelberg Engineering (instruments and unrestricted research support)
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 5552. doi:https://doi.org/
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    • Get Citation

      Jin Wook Jeoung, Hongli Yang, Stuart Keith Gardiner, Yaxing Wang, Seung Woo Hong, Michael J A Girard, Christy A Hardin, Ping Wei, Jayme Vianna, Balwantray C Chauhan, Claude F Burgoyne; Optical Coherence Tomography (OCT) Optic Nerve Head (ONH) Neural Canal Direction, Obliqueness and Minimum Cross-sectional Area in Highly Myopic versus Age-Matched Healthy Eyes. Invest. Ophthalmol. Vis. Sci. 2019;60(9):5552. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To characterize OCT-detected size, shape and 3D offset of the anterior scleral canal opening (ASCO) relative to Bruch’s membrane opening (BMO) so as to determine ONH neural canal (NC) direction, NC obliqueness and NC minimum cross-sectional area (NCMCA) (Fig.1) in 36 highly myopic (≤ -6D spherical equivalent) and 108 age-matched control subjects.

Methods : For each eye, axial length (AL) measurement and ONH OCT imaging (24 enhanced depth, radial B-scans acquired relative to the Fovea-BMO (FoBMO) axis) were performed. Within each OCT data set, BMO and ASCO were manually segmented (Fig 1A), BMO and ASCO fitted planes, centroids and area were calculated (Fig 1B), the NC axis vector was defined by connecting BMO and ASCO centroids; and NC obliqueness was defined by the angle between the NC axis and BMO perpendicular vectors. ASCO/BMO offset magnitude and direction were defined relative to BMO centroid by projecting the NC axis vector and ASCO centroid to the BMO plane (Fig 1B). NCMCA was defined by projecting all BMO and ASCO points onto an NC axis perpendicular plane and quantifying their area of overlap (Fig 1C). The shape of BMO, ASCO and NCMCA was defined by each opening’s long/short axis ratio.

Results : To date, 36 myopic eyes (median AL 27.32 mm, range 26.08 to 30.74 mm) and 108 control eyes (median AL 23.55 mm, range 21.41 to 25.89 mm) have been studied. ASCO/BMO offset direction was nasal in 35 myopic eyes (97.2%), and superior-nasal offset was more frequent in myopic (77.8%) compared to control (58.3%) (P=0.036, chi-squared test) eyes (Fig 2A). Both ASCO/BMO offset magnitude (Fig 2A) and NC obliqueness (Fig 2B), were significantly higher in myopic (287±137 µm and 65.8°±13.9°) compared to control (132±51 µm and 40.5°±16.0°) eyes (each comparison P<0.0001, t-test). While BMO area was significantly larger in myopic (2.33±0.89 mm2) compared to control (1.79±0.35 mm2, P<0.0001) eyes, ASCO and NCMCA were not different. NCMCA was significantly more elliptical in myopic (shape index 2.90±1.07) compared to control (1.55±0.60, P<0.001, t-test) eyes (Fig 2C).

Conclusions : Increased ASCO/BMO offset (most commonly occurring in the superior-nasal quadrant), increased BMO area, increased NC obliqueness and a more elliptical NCMCA underlie the OCT ONH phenotype of the highly myopic eye.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

 

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