July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Tear cytokines and conjunctival microvascular alterations in dry eye patients in responses to anti-inflammation treatment
Author Affiliations & Notes
  • YUQING DENG
    Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, Guangdong, China
  • Jianhua Wang
    Department of Ophthalmology, Bascom Palmer Eye Institute,, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Hong Jiang
    Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Ophthalmology, Bascom Palmer Eye Institute,, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Jin Yuan
    Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, Guangdong, China
  • Footnotes
    Commercial Relationships   YUQING DENG, None; Jianhua Wang, None; Hong Jiang, None; Jin Yuan, None
  • Footnotes
    Support  National Key R&D Program of China (2017YFC0112400 and 2017YFC0112402);National Natural Science Foundation of China (81670826).
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 6735. doi:https://doi.org/
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    • Get Citation

      YUQING DENG, Jianhua Wang, Hong Jiang, Jin Yuan; Tear cytokines and conjunctival microvascular alterations in dry eye patients in responses to anti-inflammation treatment. Invest. Ophthalmol. Vis. Sci. 2019;60(9):6735. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To characterize the alterations of tear cytokines and conjunctival microvascular parameters in patients with dry eye (DE) in responses to anti-inflammation treatment.

Methods : Nine patients with DE (3 females and 6 males, aged 37.8 ± 9.8 years, mean ± standard deviation) were recruited and filled out the ocular surface disease index (OSDI). The levels of inflammatory cytokines in tears were measured in these patients. The conjunctival blood flow velocities (BFVs), blood flow rate (BFR) and vessel diameters were measured using Functional Slit-lamp Biomicroscopy (FSLB). Other clinical measurements were also administrated including the noninvasive tear-film break-up times (NI-fBUT and NI-avBUT), the hyperemia index (HI) of the bulbar conjunctiva, OSDI, Schirmer I test (ST) scores and corneal fluorescein staining (CFS) scores. The repeat measurements were performed at 30 and 60 days during anti-inflammation treatment.

Results : The conjunctival BFR, BFVs, vessel diameters and HI; tumour necrosis factor alpha (TNF-α), interleukin (IL)-12 and IL-17α levels; OSDI and CFS scores were significantly lower 60 days after commencement of anti-inflammatory therapy than at baseline (all p corrected < 0.05). Significant increases in NI-fBUT, ST and NI-avBUT were observed. Moreover, BFVs was positively correlated with the levels of TNF-α (r = 0.52, p < 0.01), IL-12 (r = 0.39, p < 0.05) and IL-17α (r = 0.45, p < 0.05). BFR was significantly correlated with TNF-α levels (r = 0.48, p < 0.05), as was vessel diameter (r = 0.39, p < 0.05).

Conclusions : This study reveals the significant correlation between inflammatory cytokines and conjunctival microvascular alterations in responses to anti-inflammatory treatment in dry eye patients. The results suggest that conjunctival BFV, BFR, HI and vessel diameter may be used as directly imaging markers for evaluating ocular surface inflammatory state and treatment efficacy in DE.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

Figure 1: Correlations between microcirculatory parameters and inflammatory cytokines.
All data regarding both inflammatory cytokines and bulbar microvascular and microcirculatory parameters from baseline and 30 and 60 days after commencement of anti-inflammatory treatment were included in the analysis (27 cases in total). Significant correlations were noted between the post-treatment microvascular changes and the levels of inflammatory cytokines (IL-12, IL-17α, and TNF-α).

Figure 1: Correlations between microcirculatory parameters and inflammatory cytokines.
All data regarding both inflammatory cytokines and bulbar microvascular and microcirculatory parameters from baseline and 30 and 60 days after commencement of anti-inflammatory treatment were included in the analysis (27 cases in total). Significant correlations were noted between the post-treatment microvascular changes and the levels of inflammatory cytokines (IL-12, IL-17α, and TNF-α).

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