July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
In-vivo evaluation of corneal collagen fibrils pattern to detect keratoconus
Author Affiliations & Notes
  • Vito Romano
    Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom
    Ophthalmology, Royal Liverpool Univeristy Hospital, Liverpool, United Kingdom
  • Dr. Davide Borroni
    Ophthalmology, Royal Liverpool Univeristy Hospital, Liverpool, United Kingdom
    Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom
  • Brendan Geraghty
    Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom
  • Eugenio Lipari
    Phronema srl, Bari, Italy
  • Alessandra Sborgia
    University of Bari, Taranto, Italy
  • Yalin Zheng
    Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom
  • Stephen B Kaye
    Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom
    Ophthalmology, Royal Liverpool Univeristy Hospital, Liverpool, United Kingdom
  • Bryan Williams
    Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom
  • Footnotes
    Commercial Relationships   Vito Romano, None; Dr. Davide Borroni, None; Brendan Geraghty, None; Eugenio Lipari, Phronema (E); Alessandra Sborgia, Phronema (E); Yalin Zheng, None; Stephen Kaye, None; Bryan Williams, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 331. doi:
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      Vito Romano, Dr. Davide Borroni, Brendan Geraghty, Eugenio Lipari, Alessandra Sborgia, Yalin Zheng, Stephen B Kaye, Bryan Williams; In-vivo evaluation of corneal collagen fibrils pattern to detect keratoconus. Invest. Ophthalmol. Vis. Sci. 2019;60(9):331.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate a method for discriminating changes in the pattern of corneal collagen fibrils to detect keratoconus (KC).

Methods : Patients with KC and healthy controls were included in this prospective study. Corneal tomography (Pentacam) was taken as well as interferometric analysis of diffractive and polarizing effects related to the birefringent properties of corneal collagen fibrils (Lumaxis device, Phronema S.r.l., Bari, Italy). Three scans of each eye per patient were acquired. Custom software was developed to improve the visualisation of the representative cross by extracting the histogram equalised luminance to provide a numerical outcome to characterise the We then fit a set of ellipses to the image in a semi-automatic approach, aiming to capture the boundaries of the iris, pupil, each four quadrants of the cross, and the upper and lower eyelids. Combining this information, we are able to obtain cross (called cross parameter). A correlation between cross outcome and Kmax was calculated.

Results : A total of sixty eyes of sixty patients were included: 30 healthy subjects and 30 patients with KC. The control group included 60 eyes, mean age of 38.0 ± 13.2 years. The KC group comprised 60 eyes, mean age of 39.2 ± 12.9 years. Maximum keratometry value were 59.4 ± 11.2 D in the KC group and 45.3 ± .8 D in the healthy group. The cross parameter was 0.41 ± 0.028 in the KC group and 0.24 ± 0.055 in the healthy group. Using only measures taken from the cross resulting from the Lumaxis scan, we were able to distinguish between KC and healthy eyes.

Conclusions : The interferometric analysis of diffractive and polarizing effects related to the birefringent properties provide new morphological information at corneal fibrils level. A different corneal pattern of corneal collagen fibrils can be recognised in keratoconus patients compared to healthy patients.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

 

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